Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Propylene Carbonate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >5000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >5000 mg/kg bw/day | oral | code:3544 | oral | REACH |
| NOAEL | >1000 2106 | 1991 | code:3544 | inhalation | REACH |
Expert Verdict
Irritant when undiluted; moderate eye irritation at high concentrations; safe up to ~50% in leave-on (used up to 17.9%); insufficient data for airbrush delivery; not genotoxic, not carcinogenic
Regulatory Flags
Frequently Asked Questions
Is Propylene Carbonate safe in cosmetics?
Irritant when undiluted; moderate eye irritation at high concentrations; safe up to ~50% in leave-on (used up to 17.9%); insufficient data for airbrush delivery; not genotoxic, not carcinogenic The EU classifies Propylene Carbonate as "permitted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.
Is Propylene Carbonate allowed in the EU?
Propylene Carbonate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Propylene Carbonate do in cosmetics?
Propylene Carbonate functions as: Solvent, Viscosity-decreasing agent. It is classified as a cosmetic ingredient in our database. CAS number: 108-32-7.
What is the Margin of Safety for Propylene Carbonate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Propylene Carbonate?
The NOAEL (No Observed Adverse Effect Level) for Propylene Carbonate is >5000 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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