What is the NOAEL for Dimethyl malonate?
Dimethyl malonate has 7 NOAEL studies in the database. The lowest reported value is EM8Y79998C UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dimethyl malonate
Also known as: Propanedioic acid, dimethyl ester, 1,3-Dimethyl propanedioate, EINECS 203-597-8, UNII-EM8Y79998C
CAS 108-59-8
Dimethyl malonate (CAS 108-59-8) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
7
SOURCE
Chemical inventory jurisdictions
Regulatory lists
2
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
9 fields
Name
Dimethyl malonate
CAS Number
108-59-8
Molecular Formula
C5H8O4
InChI Key
BEPAFCGSDWSTEL-UHFFFAOYSA-N
Monoisotopic Mass
132.042259
Synonyms
Propanedioic acid, dimethyl ester1,3-Dimethyl propanedioateEINECS 203-597-8UNII-EM8Y79998C
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
3 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| EM8Y79998C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 5400 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| =5331 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB HESS |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dimethyl malonate | 203-597-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL1986332
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Dimethyl malonate?
Dimethyl malonate appears on 2 regulatory/inventory lists including Europe, SCIL (9/2019). Source: EPA CPDat.
Is Dimethyl malonate used in cosmetics?
Yes, Dimethyl malonate is also indexed as a cosmetic ingredient under the name DIMETHYL MALONATE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dimethyl malonate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Dimethyl malonate used outside industrial chemicals?
Dimethyl malonate also appears in cosmetics, pharmaceutical, cannabis databases.