Good Cosmetic Ingredient NOAEL Data

DIMETHYL MALONATE

CAS Number
108-59-8
Function
Perfuming
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status Permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

1 study endpoint found for DIMETHYL MALONATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 300 mg/kg bw/day oral rat oral REACH

Expert Verdict

DIMETHYL MALONATE is listed in the EU CosIng database with functions: Perfuming It is permitted in the EU without specific restrictions.

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Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted fragrance needs-enrichment epa_safer_alternative

Frequently Asked Questions

Is DIMETHYL MALONATE safe in cosmetics?

DIMETHYL MALONATE is listed in the EU CosIng database with functions: Perfuming It is permitted in the EU without specific restrictions. The EU classifies DIMETHYL MALONATE as "Permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is DIMETHYL MALONATE allowed in the EU?

DIMETHYL MALONATE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does DIMETHYL MALONATE do in cosmetics?

DIMETHYL MALONATE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 108-59-8.

What is the NOAEL for DIMETHYL MALONATE?

The NOAEL (No Observed Adverse Effect Level) for DIMETHYL MALONATE is 300 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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