What is the NOAEL for 1,3,5-Trihydroxybenzene?
1,3,5-Trihydroxybenzene has 7 NOAEL studies in the database. The lowest reported value is 4.93 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1,3,5-Trihydroxybenzene
Also known as: 4-06-00-07361, BRN 1341907, EINECS 203-611-2, 5-Hydroxyresorcinol, UNII-DHD7FFG6YS (+14 more)
CAS 108-73-6
1,3,5-Trihydroxybenzene (CAS 108-73-6) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
1,3,5-Trihydroxybenzene is classified GHS CMR hazard (H315, H317, H319, H335, H341, H361, H412) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
7
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
24 fields
Name
1,3,5-Trihydroxybenzene
CAS Number
108-73-6
Molecular Formula
C6H6O3
InChI Key
QCDYQQDYXPDABM-UHFFFAOYSA-N
Monoisotopic Mass
126.031694
Synonyms
4-06-00-07361BRN 1341907EINECS 203-611-25-HydroxyresorcinolUNII-DHD7FFG6YS1,3, 5-Trihydroxybenzene1,3,5-Benzenetriol (ACD/Name 4.0)1,3,5-Trihydroxy-Benzene1,3,5-Trihydroxycyclohexatriene1,3,5-Triol3,5-Dihydroxyphenol5-Benzenetriol
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =4.93 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| DHD7FFG6YS | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =4000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| >620 | ppm | LEL | oral | Rat | ECHA |
| =300 | mg/kg bw/day | NOEL | oral | Rat | ECHA |
| >400 | mg/kg bw/day | NOEL | oral | Rat | ECHA |
| >800 | mg/kg bw/day | NOEL | oral | Rat | ECHA |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Phloroglucinol | 203-611-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
PHLOROGLUCINOL
ChEMBL Phase
3
Adverse Events
266
Bioactivity
4
Frequently Asked Questions
What regulatory lists include 1,3,5-Trihydroxybenzene?
1,3,5-Trihydroxybenzene appears on 3 regulatory/inventory lists including banned; Europe; Personal care, active_ingredient; animal_products; Europe; pharmaceutical; residue, Canada; pharmaceutical. Source: EPA CPDat.
Is 1,3,5-Trihydroxybenzene used in cosmetics?
Yes, 1,3,5-Trihydroxybenzene is also indexed as a cosmetic ingredient under the name Phloroglucinol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,3,5-Trihydroxybenzene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 1,3,5-Trihydroxybenzene have different safety status in cosmetics vs industrial chemicals?
1,3,5-Trihydroxybenzene is classified GHS CMR hazard (H315, H317, H319, H335, H341, H361, H412) in the chemicals database but is allowed in EU cosmetics.
Is 1,3,5-Trihydroxybenzene used outside industrial chemicals?
1,3,5-Trihydroxybenzene also appears in cosmetics, pharmaceutical databases.