Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Phloroglucinol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | 300 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
CIR Expert Panel (1995) concluded insufficient data to determine safety due to positive genotoxicity in two assays, GHS Skin Sens. 1 classification, absent dermal absorption data, and lack of margin of safety calculation.
Regulatory Flags
Frequently Asked Questions
Is Phloroglucinol safe in cosmetics?
CIR Expert Panel (1995) concluded insufficient data to determine safety due to positive genotoxicity in two assays, GHS Skin Sens. 1 classification, absent dermal absorption data, and lack of margin of safety calculation. The EU classifies Phloroglucinol as "permitted". Safety rating: POOR. 1 toxicological study endpoint(s) are available in our database.
Is Phloroglucinol allowed in the EU?
Phloroglucinol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phloroglucinol do in cosmetics?
Phloroglucinol functions as: Hair Dyeing Coupler, Antioxidant, Anti-Melanogenic. It is classified as a Cosmetic Ingredient in our database. CAS number: 108-73-6.
What is the Margin of Safety for Phloroglucinol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Phloroglucinol?
The NOAEL (No Observed Adverse Effect Level) for Phloroglucinol is 300 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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