Warning GHS08 NOAEL Data IARC Group 2B SVHC REACH Registered Cosmetic Ingredient

Melamine

Also known as: 1,3,5-Triazine-2,4,6-triamine, 4-26-00-01253, BRN 0124341, EINECS 203-615-4, Hicophor PR (+5 more)

CAS 108-78-1

Melamine (CAS 108-78-1) is a chemical substance with GHS signal word Warning; key hazard signal: H351; H373 (urinary tract). Key regulatory status: SVHC Candidate List, REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ECHA SVHC, ILO ICSC.

View cosmetic safety profile for Melamine →

Cross-Vertical Regulatory Divergence

Melamine is prohibited in EU cosmetics but has active industrial GHS classifications (H351, H373).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

100

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 16 fields

Name

Melamine

CAS Number

108-78-1

DTXSID

DTXSID6020802

Molecular Formula

C3H6N6

InChI Key

JDSHMPZPIAZGSV-UHFFFAOYSA-N

Monoisotopic Mass

126.065394

Synonyms

1,3,5-Triazine-2,4,6-triamine4-26-00-01253BRN 0124341EINECS 203-615-4Hicophor PRNCI-C50715s-Triazine, 2,4,6-triamino-UNII-N3GP2YSD88Cyanuric triamidesym-triaminotriazine

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 2B	Possibly carcinogenic	2017	Sup 7, 73, 119

Substance of Very High Concern (SVHC)

Candidate List status and reason under the ECHA REACH SVHC program.

SOURCE ECHA (EU) 1 records

Substance	Reason	Included
Melamine	Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health); Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)	17-Jan-2023

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Carc. 2; STOT RE 2	H351; H373 (urinary tract)	GHS08	Warning

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 21 records

Flame retardantDegradant/impurityMonomersChemical reaction regulatorNo specific technical function

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records

List	Keyword	Source
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Europe; plastic_additive	European Chemicals Agency	European Chemicals Agency (ECHA)
inert_ingredient; non_food_use; Pesticides	EPA	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies

Value	Unit	Endpoint	Route	Species	Source
range:0-0.00070.0007	mg/kg bw/day	ADI	-	Rat	INCHEM_WHO_jmpr_jmpmono_v2006pr01
range:0-0.0050.005	mg/kg bw/day	ADI	-	Rat	INCHEM_WHO_jmpr_jmpmono_v2006pr01
range:0-0.010.01	mg/kg bw/day	ADI	-	Dog	INCHEM_WHO_jmpr_jmpmono_v2006pr01
range:0-0.020.02	mg/kg bw/day	ADI	oral	-	INCHEM_WHO_jmpr_jmpmono_v2006pr01
range:0-0.040.04	mg/kg bw/day	ADI	oral	Rat	INCHEM_WHO_jmpr_jmpmono_v2006pr01
range:0-0.050.05	mg/kg bw/day	ADI	-	-	INCHEM_WHO_jmpr_jmpmono_v2006pr01
range:0-0.060.06	mg/kg bw/day	ADI	oral	Rat	INCHEM_WHO_jmpr_jmpmono_v2006pr01
range:0-0.10.1	mg/kg bw/day	ADI	-	-	INCHEM_WHO_jmpr_jmpmono_v2006pr01
range:0-0.20.2	mg/kg bw/day	ADI	oral	Rat; Dog	INCHEM_WHO_jmpr_jmpmono_v2006pr01
=19	mg/kg bw/day	BMDL (10)	oral	Rat	ToxValDB_EFSA
=8.3	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
N3GP2YSD88	UNII	FDA UNII substance identifier	-	-	openFDA substances
N3GP2YSD88	UNII	FDA UNII substance identifier	-	-	openFDA substances
N3GP2YSD88	UNII	FDA UNII substance identifier	-	-	openFDA substances
N3GP2YSD88	UNII	FDA UNII substance identifier	-	-	openFDA substances
2B	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
2B	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
2B	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
2	unitless	IARC group	-	-	NTP_ICE_cancer
3.248	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=3160	mg/kg bw	LD50	oral	Rat (Male)	NTP_ICE_acute_oral
=3161	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=3200	mg/kg bw	LD50	oral	Rat (Male)	NTP_ICE_acute_oral
=3800	mg/kg bw	LD50	oral	Rat (Female)	NTP_ICE_acute_oral
=3850	mg/kg bw	LD50	oral	Rat (Female)	NTP_ICE_acute_oral
=181	mg/kg bw/day	LEL	oral	Cat	ToxValDB_EFSA
=225	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=225	mg/kg bw/day	LEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=250	mg/kg bw/day	LEL	oral	Rabbit	ToxValDB_EPA_TSCA_8e
=337.5	mg/kg bw/day	LEL	oral	Mouse	ToxValDB_ToxRefDB
=337.5	mg/kg bw/day	LEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
=400	mg/kg bw/day	LEL	oral	Pig	ToxValDB_EFSA
=400	mg/kg bw/day	LEL	oral	Rabbit	ToxValDB_EPA_TSCA_8e
=1000	mg/kg bw/day	LEL	oral	Rabbit	ToxValDB_EPA_TSCA_8e
=0.2	mg/kg bw/day	LOAEL	-	Rat; Mouse	INCHEM_WHO_jmpr_jmpmono_v2006pr01
=0.6	mg/kg bw/day	LOAEL	-	Mouse	INCHEM_WHO_jmpr_jmpmono_v2006pr01
=1	mg/kg bw/day	LOAEL	-	Rat	INCHEM_WHO_jmpr_jmpmono_v2006pr01
=1.5	mg/kg bw/day	LOAEL	-	Rat; Mouse	INCHEM_WHO_jmpr_jmpmono_v2006pr01
=2	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
=2.5	mg/kg bw	LOAEL	-	Human; Rat	INCHEM_WHO_jmpr_jmpmono_v2006pr01
=2.5	mg/kg bw/day	LOAEL	-	-	INCHEM_WHO_jmpr_jmpmono_v2006pr01
=6.2	mg/kg bw/day	LOAEL	-	Rat	INCHEM_WHO_jmpr_jmpmono_v2006pr01
=6.3	mg/kg bw/day	LOAEL	-	Rat; Mouse	INCHEM_WHO_jmpr_jmpmono_v2006pr01
=6.9	mg/kg bw/day	LOAEL	-	-	INCHEM_WHO_jmpr_jmpmono_v2006pr01
=6.9	mg/kg bw/day	LOAEL	-	-	INCHEM_WHO_jmpr_jmpmono_v2006pr01
=8.9	mg/kg bw/day	LOAEL	-	-	INCHEM_WHO_jmpr_jmpmono_v2006pr01
=8.9	mg/kg bw/day	LOAEL	-	-	INCHEM_WHO_jmpr_jmpmono_v2006pr01
=9.4	mg/kg bw/day	LOAEL	oral	Rat	INCHEM_WHO_jmpr_jmpmono_v2006pr01
=9.7	mg/kg bw/day	LOAEL	oral	-	INCHEM_WHO_jmpr_jmpmono_v2006pr01
=9.7	mg/kg bw/day	LOAEL	oral	-	INCHEM_WHO_jmpr_jmpmono_v2006pr01

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Melamine	203-615-4	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1231106

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: 0.2 mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Melamine?

Melamine (CAS 108-78-1) is classified under EU CLP Annex VI as Carc. 2; STOT RE 2 with signal word Warning. Hazard statements: H351; H373 (urinary tract). Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Melamine?

Melamine has 100 NOAEL studies in the database. The lowest reported value is 0 mg/kg bw/day via oral in mouse (b6c3f1; B6C3F1). Source: ToxRefDB_ToxRefDB_v3_pod.csv.

What regulatory lists include Melamine?

Melamine appears on 5 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, Indirect additives food contact (10/2018), detected; Europe; Toys and children's products, and 2 more. Source: EPA CPDat.

Is Melamine a carcinogen according to IARC?

Melamine is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 2017). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is Melamine a Substance of Very High Concern (SVHC)?

Yes, Melamine is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health); Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment). Source: ECHA SVHC Candidate List.

Is Melamine used in cosmetics?

Yes, Melamine is also indexed as a cosmetic ingredient under the name Melamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Melamine come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ECHA SVHC Candidate List, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Melamine have different safety status in cosmetics vs industrial chemicals?

Melamine is prohibited in EU cosmetics but has active industrial GHS classifications (H351, H373).

Is Melamine used outside industrial chemicals?

Melamine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.