Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Melamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 12000 ppm | oral | rat | oral | REACH |
| NOAEL | 750 ppm | oral | rat | oral | REACH |
| NOAEL | 60 mg/kg bw/day | other | monkey | oral | REACH |
| NOEL | ca.5000 ppm | oral | rat | oral | REACH |
| NOEL | ca.15000 ppm | oral | mouse | oral | REACH |
| NOAEL | 140 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | ca.1000 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 30000 mg/kg bw/day | oral | dog | oral | REACH |
| NOAEL | 126 mg/kg bw/day | oral | code:3544 | oral | REACH |
| NOAEL | 200 mg/kg bw/day | oral | pig | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Classified Carc. 2 (suspected carcinogen); renal toxicity established in oral exposure studies; kidney stone formation; strictly prohibited in EU cosmetics; not acceptable in any cosmetic formulation
Regulatory Flags
Frequently Asked Questions
Is Melamine safe in cosmetics?
Classified Carc. 2 (suspected carcinogen); renal toxicity established in oral exposure studies; kidney stone formation; strictly prohibited in EU cosmetics; not acceptable in any cosmetic formulation The EU classifies Melamine as "prohibited". Safety rating: POOR. 10 toxicological study endpoint(s) are available in our database.
Is Melamine allowed in the EU?
Melamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Melamine do in cosmetics?
Melamine functions as: Industrial resin precursor. It is classified as a cosmetic ingredient in our database. CAS number: 108-78-1.
What is the Margin of Safety for Melamine?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Melamine?
The NOAEL (No Observed Adverse Effect Level) for Melamine is 12000 ppm based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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