What is the GHS hazard classification for Cyclohexanone?
Cyclohexanone (CAS 108-94-1) is classified under EU CLP Annex VI as Flam. Liq. 3; Acute Tox. 4 * with signal word Warning. Hazard statements: H226; H332. Source: EU CLP Annex VI (ECHA).
Warning
GHS02GHS07
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
Cyclohexanone
Also known as: Caswell No. 270, EINECS 203-631-1, EPA Pesticide Chemical Code 025902, NCI-C55005, UNII-5QOR3YM052 (+12 more)
CAS 108-94-1
Cyclohexanone (CAS 108-94-1) is a chemical substance with GHS signal word Warning; key hazard signal: H226; H332. Key regulatory status: REACH registered, 40 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC, OSHA.
Cross-Vertical Regulatory Divergence
Cyclohexanone is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H332).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
37
SOURCE
chemical inventory jurisdictions
Regulatory lists
40
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
Cyclohexanone
CAS Number
108-94-1
DTXSID
DTXSID6020359
Molecular Formula
C6H10O
InChI Key
JHIVVAPYMSGYDF-UHFFFAOYSA-N
Monoisotopic Mass
98.073165
Synonyms
Caswell No. 270EINECS 203-631-1EPA Pesticide Chemical Code 025902NCI-C55005UNII-5QOR3YM052ANONAnoneCicloesanoneCyclic ketoneCyclohexanon(dutch)Cyclohexanone homopolymerCykloheksanon
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1998 | 47, 71 |
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 3; Acute Tox. 4 * | H226; H332 | GHS02; GHS07 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance and the vapour are irritating to the eyes, skin and respiratory tract. Exposure far above the OEL could cause lowering of consciousness. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
6 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 50 ppm (200 mg/m³) | 50 | 200 | N |
| NIOSH | TWA | 25 ppm (100 mg/m³) | 25 | 100 | Y |
| ACGIH | TWA | 20 ppm [1990] | 20 | - | Y |
| ACGIH | STEL | 50 ppm [1990] | 50 | - | Y |
| CAL/OSHA | TWA | 25 ppm (100 mg/m³) | 25 | 100 | Y |
| NIOSH | IDLH | 700 ppm | 700 | - | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
12 records
SolventFragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
40 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - home office - pens and markers; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other indirect contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; emissions; Europe; Other indirect contact consumer goods; water | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| artificial_saliva; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| artificial_sweat; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts adhesive; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cons electronics mech appliances and machinery; detected; Europe | Danish EPA | Danish EPA |
| Cons electronics mech appliances and machinery; detected; Europe | Danish EPA | Danish EPA |
| detected; Toys and children's products | Springer Berlin Heidelberg | Published Articles |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| detected; Other indirect contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 37 of 37 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =10 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 3 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 5QOR3YM052 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5QOR3YM052 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5QOR3YM052 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5QOR3YM052 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.26 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| 19 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 32.0929 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =44155.4 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| 143 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| =762.685 | mg/m3 | LOAEL | inhalation | Rabbit | ToxValDB_EU_SCOEL |
| 910 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| =910 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_IRIS |
| 6500 | ppm | LOAEL | oral | mouse | COSMOS_DB |
| 10 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 40 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =100.353 | mg/m3 | NOAEL | inhalation | Human | ToxValDB_EU_SCOEL |
| 462 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =462 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_IRIS |
| =462 | mg/kg/day | NOAEL | oral | - | EPA_IRIS_iris_rfd_systems.csv |
| =731 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_PPRTV_(CPHEA) |
| =222 | mg/m3 | NOAEL (HEC) | inhalation | Rabbit | ToxValDB_PPRTV_(CPHEA) |
| =800 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB_ECOTOX |
| 48 | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
| 5 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| =0.7 | mg/m3 | RfC | inhalation | Human | ToxValDB_Pennsylvania_DEP_ToxValues |
| =7 | mg/m3 | RfC (provisional) | inhalation | Human | ToxValDB_PPRTV_(CPHEA) |
| =5 | mg/kg bw/day | RfD | oral | Human | ToxValDB_IRIS |
| =5 | mg/kg/day | RfD | oral | - | EPA_IRIS_iris_rfd_systems.csv |
| =2 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
Showing 37 of 37 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Cyclohexanone | 203-631-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CYCLOHEXANONE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Cyclohexanone?
Cyclohexanone has 37 NOAEL studies in the database. The lowest reported value is 3 unitless via Ocular in Rabbit. Source: NTP_ICE_eye_irritation.
What regulatory lists include Cyclohexanone?
Cyclohexanone appears on 23 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, air; Cons electronics mech appliances and machinery; detected; emissions; Europe, Cons electronics mech appliances and machinery; detected; emissions; Europe, and 20 more. Source: EPA CPDat.
Is Cyclohexanone a carcinogen according to IARC?
Cyclohexanone is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
What are the occupational exposure limits for Cyclohexanone?
Occupational exposure limits for Cyclohexanone are set by OSHA, NIOSH, ACGIH. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Cyclohexanone used in cosmetics?
Yes, Cyclohexanone is also indexed as a cosmetic ingredient under the name Cyclohexanone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Cyclohexanone come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Cyclohexanone have different safety status in cosmetics vs industrial chemicals?
Cyclohexanone is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H332).
Is Cyclohexanone used outside industrial chemicals?
Cyclohexanone also appears in cosmetics, pharmaceutical, cannabis databases.