Poor Cosmetic Ingredient GHS Classified

Cyclohexanone

Also known as: Caswell No. 270, EINECS 203-631-1, EPA Pesticide Chemical Code 025902, NCI-C55005, UNII-5QOR3YM052 (+12 more)

INCI: CYCLOHEXANONE

Cyclohexanone (CAS 108-94-1) is a cosmetic cosmetic ingredient functioning as Industrial solvent and intermediate; not typically used as a final cosmetic. NOAEL 143 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.

View industrial chemical safety profile for CAS 108-94-1 →

Auto-generated CPSR Part A draft with source citations

Cross-Vertical Regulatory Divergence

Cyclohexanone is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H312, H315, H318, H332, H311, H317).

Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

CAS Number

108-94-1

View industrial chemical safety profile →

Function

Industrial solvent and intermediate; not typically used as a final cosmetic ingredient due to volatility and irritation potential.

Safety Rating

POOR

Chemistry & Identifiers

Formula

C6H10O

98.14 g/mol

EC Number

203-631-1

PubChem CID

7967

IUPAC Name

cyclohexanone

InChIKey

JHIVVAPYMSGYDF-UHFFFAOYSA-N

ChEBI: CHEBI:17854 UNII: 5QOR3YM052 Wikidata: Q409178

Regulatory Status

EU EU Status prohibited

US US Status permitted

US Notes No CIR cosmetic monograph as an ingredient; typically treated as a process solvent or intermediate in synthesis, with residual limits controlled via general safety principles.

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Cyclohexanone.

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects

The substance and the vapour are irritating to the eyes, skin and respiratory tract. Exposure far above the OEL could cause lowering of consciousness.

Routes of Exposure

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for Cyclohexanone across SCCS product categories, with measured dermal absorption where available.

IARC Carcinogenicity

International Agency for Research on Cancer (WHO) monograph evaluation.

IARC Group

Volume

47, 71

Evaluation Year

1998

EU CLP Annex VI Harmonized Classification

Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.

Signal Word

Warning

Pictograms

FlammableHarmful / Irritant

Hazard Class and Category

Flam. Liq. 3; Acute Tox. 4 *

Hazard Statements

H226 Flammable liquid and vapour
H332 Harmful if inhaled

Inserted via ATP: CLP00

HRIPT Human Patch Test Studies

1 human repeat insult patch test aggregated from dermatological literature.

Test Type	N	Sensitized	Dose µg/cm²	NESIL µg/cm²	Potency
HRIPT	-	0	-	-	-

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type

Full

Tonnage Band

100,000 - 1,000,000 tonnes

Substance Type

SUBSTANCE

SVHC Candidate

Hazard classification: Restricted (Annex XVII)

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Safety (4)

Carcinogen Classification

Cyclohexanone | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 47: (1989) Some Organic Solvents, Resin Monomers and Related Compounds, Pigments and Occupational Exposures in Paint Manufacture and Painting | Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide (Part 1, Part 2, Part 3)

Source: International Agency for Research on Cancer (IARC)

Evidence for Carcinogenicity

Evaluation: No epidemiological data relevant to the carcinogenicity of cyclohexanone were available. There is inadequate evidence in experimental animals for the carcinogenicity of cyclohexanone. Overall evaluation: Cyclohexanone is not classifiable as to its carcinogenicity to humans (Group 3). | A3; Confirmed animal carcinogen with unknown relevance to humans.

Source: Hazardous Substances Data Bank (HSDB)

ICSC Safety Card

0425

Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Skin Eye Respiratory Irritation

Inhalation of vapor can cause irritation of mucous membranes. Contact of liquid may produce dermatitis in sensitive individuals.

Source: Hazardous Substances Data Bank (HSDB)

Regulatory (6)

JECFA Number

1100