Poor Cosmetic Ingredient NOAEL Data GHS Classified

Cyclohexanone

INCI: CYCLOHEXANONE

CAS Number
108-94-1
Function
Industrial solvent and intermediate; not typically used as a final cosmetic ingredient due to volatility and irritation potential.
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes No CIR cosmetic monograph as an ingredient; typically treated as a process solvent or intermediate in synthesis, with residual limits controlled via general safety principles.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Cyclohexanone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 40 mg/kg bw/day oral rat Subchronic COSMOS_DB
LOAEL 143 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 462 mg/kg bw/day oral rat Chronic COSMOS_DB
LOAEL 910 mg/kg bw/day oral rat Chronic COSMOS_DB
LOAEL 6500 ppm oral mouse Chronic COSMOS_DB
NOAEL 100 ppm 1995 code:3544 inhalation REACH
NOAEL 100 mg/kg bw/day intravenous rat other REACH
NOAEL 143 mg/kg bw/day oral rat oral REACH
NOAEL 462 mg/kg bw/day oral code:3544 oral REACH
NOAEL >250 ppm 1991 mouse inhalation REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance and the vapour are irritating to the eyes, skin and respiratory tract. Exposure far above the OEL could cause lowering of consciousness.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Expert Verdict

Cyclohexanone poses eye and skin irritation, CNS effects via inhalation, and flammability risks; risk-benefit is unfavorable for deliberate cosmetic use.

⚠️
Concern Level: High

Regulatory Flags

endocrine_disruptor ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Cyclohexanone safe in cosmetics?

Cyclohexanone poses eye and skin irritation, CNS effects via inhalation, and flammability risks; risk-benefit is unfavorable for deliberate cosmetic use. The EU classifies Cyclohexanone as "prohibited". Safety rating: POOR. 10 toxicological study endpoint(s) are available in our database.

Is Cyclohexanone allowed in the EU?

Cyclohexanone EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Cyclohexanone do in cosmetics?

Cyclohexanone functions as: Industrial solvent and intermediate; not typically used as a final cosmetic ingredient due to volatility and irritation potential.. It is classified as a cosmetic ingredient in our database. CAS number: 108-94-1.

What is the Margin of Safety for Cyclohexanone?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Cyclohexanone?

The NOAEL (No Observed Adverse Effect Level) for Cyclohexanone is 40 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Cyclohexanone compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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