What is the NOAEL for Dibutyl decanedioate?
Dibutyl decanedioate has 9 NOAEL studies in the database. The lowest reported value is 134 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dibutyl decanedioate
Also known as: Dibutyl sebacate, 4-02-00-02081, Bis(n-butyl)sebacate, BRN 1798308, Butyl sebacate (+8 more)
CAS 109-43-3
Dibutyl decanedioate (CAS 109-43-3) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
Dibutyl decanedioate
CAS Number
109-43-3
DTXSID
DTXSID1041847
Molecular Formula
C18H34O4
InChI Key
PYGXAGIECVVIOZ-UHFFFAOYSA-N
Monoisotopic Mass
314.24571
Synonyms
Dibutyl sebacate4-02-00-02081Bis(n-butyl)sebacateBRN 1798308Butyl sebacateDibutyl 1,8-octanedicarboxylateDibutyl sebacinateDi-n-butylsebacateEINECS 203-672-5FEMA No. 2373Monoplex DBSDibutylester kyseliny sebakove
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
29 records
SolventSoftener and conditionerFilm formerPlasticizerDeodorizerFlavouring and nutrientFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 134 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 4W5IH7FLNY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4W5IH7FLNY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4W5IH7FLNY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4W5IH7FLNY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7.05e-8 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 625 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3125 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dibutyl sebacate | 203-672-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DIBUTYL SEBACATE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
What regulatory lists include Dibutyl decanedioate?
Dibutyl decanedioate appears on 7 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, Europe; plastic_additive, IFRA Transparency, and 4 more. Source: EPA CPDat.
Is Dibutyl decanedioate used in cosmetics?
Yes, Dibutyl decanedioate is also indexed as a cosmetic ingredient under the name Dibutyl Sebacate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dibutyl decanedioate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Dibutyl decanedioate used outside industrial chemicals?
Dibutyl decanedioate also appears in cosmetics, pharmaceutical databases.