Is Dibutyl Sebacate safe in cosmetics?
Dibutyl Sebacate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Dibutyl Sebacate
Also known as: 4-02-00-02081, Bis(n-butyl)sebacate, BRN 1798308, Butyl sebacate, Dibutyl 1,8-octanedicarboxylate (+7 more)
INCI: DIBUTYL SEBACATE
Dibutyl Sebacate (CAS 109-43-3) is a cosmetic cosmetic ingredient functioning as Film forming, plasticizer, hair and skin conditioning, masking, solvent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 109-43-3 →
Auto-generated CPSR Part A draft with source citations
Function
Film forming, plasticizer, hair and skin conditioning, masking, solvent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
dibutyl decanedioate
InChIKey
PYGXAGIECVVIOZ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no CFR restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dibutyl Sebacate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization.
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: other
Receptor targets: AR (weak)
LOEC: 10 µM
EU status: allowed
weak antagonist
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Nail Polish | 5–15 | 30 | CIR |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
ICSC Safety Card
1349
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Regulatory (2)
JECFA Number
625
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
BUTYL SEBACATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | Secondary components do not raise a safety concern | TRS 913-JECFA 59/111 | FAS 44-JECFA 53/229 (1999)
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Film former
Flavouring and nutrient
Fragrance
Plasticizer
Softener and conditioner
Solvent
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Dibutyl Sebacate.
Regulatory Flags
epa_safer_alternative
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dibutyl Sebacate by CAS number or substance name.
Studies
18
Lowest NOAEL
178 mg/kg bw/day
Highest NOAEL
2187 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
4-02-00-02081
Bis(n-butyl)sebacate
BRN 1798308
Butyl sebacate
Dibutyl 1,8-octanedicarboxylate
Dibutyl sebacinate
Di-n-butylsebacate
EINECS 203-672-5
FEMA No. 2373
Monoplex DBS
Dibutylester kyseliny sebakove
UNII-4W5IH7FLNY
Chemical Function
Solvent
Softener and conditioner
Film former
Plasticizer
Deodorizer
Flavouring and nutrient
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
Europe; plastic_additive
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DIBUTYL SEBACATE
ChEMBL ID
CHEMBL2106225
Max Phase
-1
Frequently Asked Questions
Is Dibutyl Sebacate allowed in the EU?
Dibutyl Sebacate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dibutyl Sebacate do in cosmetics?
Dibutyl Sebacate functions as: Film forming, plasticizer, hair and skin conditioning, masking, solvent. It is classified as a cosmetic ingredient in our database. CAS number: 109-43-3.
Is Dibutyl Sebacate used outside cosmetics?
Dibutyl Sebacate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dibutyl Sebacate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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