Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Dibutyl Sebacate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 3125 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 625 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| dose_tested | 3125 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| dose_tested | 625 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Some SDS sources classify as Skin Irrit. 2 / Eye Irrit. 2A (may vary by purity/grade). No mutagenic, carcinogenic, or reproductive effects reported. Generally well-tolerated at cosmetic use levels.
Regulatory Flags
Frequently Asked Questions
Is Dibutyl Sebacate safe in cosmetics?
Some SDS sources classify as Skin Irrit. 2 / Eye Irrit. 2A (may vary by purity/grade). No mutagenic, carcinogenic, or reproductive effects reported. Generally well-tolerated at cosmetic use levels. The EU classifies Dibutyl Sebacate as "permitted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.
Is Dibutyl Sebacate allowed in the EU?
Dibutyl Sebacate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dibutyl Sebacate do in cosmetics?
Dibutyl Sebacate functions as: Film forming, plasticizer, hair and skin conditioning, masking, solvent. It is classified as a cosmetic ingredient in our database. CAS number: 109-43-3.
What is the Margin of Safety for Dibutyl Sebacate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dibutyl Sebacate?
The NOAEL (No Observed Adverse Effect Level) for Dibutyl Sebacate is 3125 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Dibutyl Sebacate compliance across multiple jurisdictions:
Related Ingredients
Is Dibutyl Sebacate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Dibutyl Sebacate in your formulation.