What is the NOAEL for Propyl acetate?
Propyl acetate has 12 NOAEL studies in the database. The lowest reported value is 420 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Propyl acetate
Also known as: acetic acid, propyl ester, 4-02-00-00138, BRN 1740764, EINECS 203-686-1, FEMA No. 2925 (+7 more)
CAS 109-60-4
Propyl acetate (CAS 109-60-4) is a chemical substance. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
Cross-Vertical Regulatory Divergence
Propyl acetate is classified GHS Danger (H225, H319, H336, H316, H320, H333, H335, H370) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
9
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Propyl acetate
CAS Number
109-60-4
DTXSID
DTXSID6021901
Molecular Formula
C5H10O2
InChI Key
YKYONYBAUNKHLG-UHFFFAOYSA-N
Monoisotopic Mass
102.06808
Synonyms
acetic acid, propyl ester4-02-00-00138BRN 1740764EINECS 203-686-1FEMA No. 2925Acetate de propyle normalOctan propyluPropylester kyseliny octoveUNII-4AWM8C91G6Acetic acid, N-propyl esterAcetic acid,propyl esterN-Propyl ethanoate
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Highly flammable liquid and vapour May cause drowsiness or dizziness Harmful to aquatic life |
| Short-term Effects | The vapour is mildly irritating to the eyes, respiratory tract and skin. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of consciousness. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
8 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 200 ppm (840 mg/m³) | 200 | 840 | N |
| NIOSH | TWA | 200 ppm (840 mg/m³) | 200 | 840 | N |
| NIOSH | STEL | 250 ppm (1050 mg/m³) | 250 | 1050 | N |
| ACGIH | TWA | 100 ppm [2017] | 100 | - | N |
| ACGIH | STEL | 150 ppm [2017] | 150 | - | N |
| CAL/OSHA | TWA | 200 ppm (840 mg/m³) | 200 | 840 | N |
| CAL/OSHA | STEL | 250 ppm (1050 mg/m³) | 250 | 1050 | N |
| NIOSH | IDLH | 1700 ppm | 1700 | - | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
15 records
SolventFragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
9 records
| List | Keyword | Source |
|---|---|---|
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| air; Arts and crafts/Office supplies - fabric treatment and dye; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =420 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 4AWM8C91G6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4AWM8C91G6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4AWM8C91G6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4AWM8C91G6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 32 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =9370 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =9800 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =71013.1 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =900 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =900 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Propyl acetate | 203-686-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ACETIC ACID PROPYL ESTER
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Propyl acetate?
Propyl acetate appears on 9 regulatory/inventory lists including consumer_product; detected; Europe, inert_ingredient; non_food_use; Pesticides, air; Arts and crafts/Office supplies - fabric treatment and dye; detected; emissions; Europe, and 6 more. Source: EPA CPDat.
What are the occupational exposure limits for Propyl acetate?
Occupational exposure limits for Propyl acetate are set by OSHA, NIOSH, ACGIH. 8 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Propyl acetate used in cosmetics?
Yes, Propyl acetate is also indexed as a cosmetic ingredient under the name Propyl Acetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Propyl acetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Propyl acetate have different safety status in cosmetics vs industrial chemicals?
Propyl acetate is classified GHS Danger (H225, H319, H336, H316, H320, H333, H335, H370) in the chemicals database but is restricted in EU cosmetics.
Is Propyl acetate used outside industrial chemicals?
Propyl acetate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.