Is Propyl Acetate safe in cosmetics?
Propyl Acetate has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Propyl Acetate
Also known as: acetic acid, propyl ester, 4-02-00-00138, BRN 1740764, EINECS 203-686-1, FEMA No. 2925 (+7 more)
INCI: PROPYL ACETATE
Propyl Acetate (CAS 109-60-4) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient, Solvent. Reported NOAEL =1000 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: restricted; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 109-60-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Propyl Acetate is classified GHS Danger (H225, H319, H336, H316, H320, H333, H335, H370) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance ingredient, Solvent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
propyl acetate
InChIKey
YKYONYBAUNKHLG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted in cosmetics; CIR assessed safe in present practices of use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Propyl Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Propyl Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
FlamFlameExcl markWarn
Hazard Statements
Highly flammable liquid and vapour May cause drowsiness or dizziness Harmful to aquatic life
Short-term Exposure Effects
The vapour is mildly irritating to the eyes, respiratory tract and skin. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of consciousness.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0940
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
IN MAN, CONCN OF 200 PPM CAUSE IRRITATION OF EYES & GREATER CONCN ... /CAUSE/ IRRITATION OF NOSE & LARYNX.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Number
126
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
PROPYL ACETATE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/52 | FAS 40-JECFA 49/297
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Solvent
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Propyl Acetate.
Regulatory Flags
potential-allergen
fragrance-component
epa_safer_alternative
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Propyl Acetate by CAS number or substance name.
Studies
10
Lowest NOAEL
250 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
acetic acid, propyl ester
4-02-00-00138
BRN 1740764
EINECS 203-686-1
FEMA No. 2925
Acetate de propyle normal
Octan propylu
Propylester kyseliny octove
UNII-4AWM8C91G6
Acetic acid, N-propyl ester
Acetic acid,propyl ester
N-Propyl ethanoate
Chemical Function
Solvent
Fragrance
Flavouring and nutrient
Regulatory Lists
consumer_product; detected; Europe
inert_ingredient; non_food_use; Pesticides
air; Arts and crafts/Office supplies - fabric treatment and dye; detected; emissions; Europe
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
Canada; pharmaceutical
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ACETIC ACID PROPYL ESTER
ChEMBL ID
CHEMBL44857
Frequently Asked Questions
Is Propyl Acetate allowed in the EU?
Propyl Acetate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Propyl Acetate do in cosmetics?
Propyl Acetate functions as: Fragrance ingredient, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 109-60-4.
What is the NOAEL for Propyl Acetate?
The NOAEL (No Observed Adverse Effect Level) for Propyl Acetate is =1000 mg/kg bw/day based on a developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Propyl Acetate classified as hazardous under GHS?
Propyl Acetate carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour May cause drowsiness or dizziness Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Propyl Acetate used outside cosmetics?
Propyl Acetate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Propyl Acetate have different safety status in cosmetics vs industrial chemicals?
Propyl Acetate is classified GHS Danger (H225, H319, H336, H316, H320, H333, H335, H370) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Propyl Acetate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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