Good Cosmetic Ingredient NOAEL Data GHS Classified

Propyl Acetate

INCI: PROPYL ACETATE

CAS Number

109-60-4

Function

Fragrance ingredient, Solvent

Safety Rating

GOOD

Regulatory Status

🇪🇺 EU Status restricted

🇺🇸 US Status permitted

US Notes Permitted in cosmetics; CIR assessed safe in present practices of use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

adequate

Dermal Absorption

low

Sensitization

low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for Propyl Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	2.35 2100	1995	rat	inhalation	REACH
NOAEL	2.35 2100	1995	rat	inhalation	REACH
LOAEL	1039.2 2284	1995	rat	inhalation	REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

DANGER

Pictograms

flam;flame; excl mark;warn

Hazard Statements

Highly flammable liquid and vapour May cause drowsiness or dizziness Harmful to aquatic life

Short-term Exposure Effects

The vapour is mildly irritating to the eyes, respiratory tract and skin. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of consciousness.

Long-term Exposure Effects

The substance defats the skin, which may cause dryness or cracking.

Routes of Exposure

The substance can be absorbed into the body by inhalation of its vapour.

Expert Verdict

Flammable liquid; not PBT (not persistent, bioaccumulative, or toxic); not photoirritating/photoallergenic

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component epa_safer_alternative ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Propyl Acetate safe in cosmetics?

Flammable liquid; not PBT (not persistent, bioaccumulative, or toxic); not photoirritating/photoallergenic The EU classifies Propyl Acetate as "restricted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.

Is Propyl Acetate allowed in the EU?

Propyl Acetate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Propyl Acetate do in cosmetics?

Propyl Acetate functions as: Fragrance ingredient, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 109-60-4.

What is the Margin of Safety for Propyl Acetate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Propyl Acetate?

The NOAEL (No Observed Adverse Effect Level) for Propyl Acetate is 2.35 2100 based on a inhalation study via 1995 route in rat. A total of 3 study endpoints are available. Source: REACH.

Is Propyl Acetate classified as hazardous under GHS?

Propyl Acetate carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour May cause drowsiness or dizziness Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check Propyl Acetate compliance across multiple jurisdictions:

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Ingredient Decoder

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82 Allergen Checker

Check for EU declarable fragrance allergens

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Substance Compliance

Check compliance across 55 jurisdictions

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MoS Calculator

Calculate Margin of Safety using SCCS methodology

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Heavy Metal Limits

Compare limits across jurisdictions

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