Also known as: n-Pentane, Norpar 5S, Caswell No. 642AA, EINECS 203-692-4, EPA Pesticide Chemical Code 098001 (+7 more)
CAS 109-66-0
Pentane (CAS 109-66-0) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H304; H336; H411. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
Pentane is classified GHS Danger (H225, H304, H336, H411) in the chemicals database but is restricted in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 2; Asp. Tox. 1; STOT SE 3; Aquatic Chronic 2 | H225; H304; H336; H411 | GHS02; GHS08; GHS07; GHS09 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Highly flammable liquid and vapour May cause drowsiness or dizziness May be fatal if swallowed and enters airways Toxic to aquatic life |
| Short-term Effects | If swallowed the substance easily enters the airways and could result in aspiration pneumonitis. Inhalation of high concentrations of the vapour may cause depression of the central nervous system. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 1000 ppm (2950 mg/m³) | 1000 | 2950 | N |
| NIOSH | TWA | 120 ppm (350 mg/m³) | 120 | 350 | N |
| NIOSH | CEILING | 610 ppm (1800 mg/m³) [15 min] | 610 | 1800 | N |
| ACGIH | TWA | 1000 ppm [2013] | 1000 | - | N |
| CAL/OSHA | TWA | 600 ppm (1800 mg/m³) | 600 | 1800 | N |
| NIOSH | IDLH | 1500 ppm | 1500 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| air; detected; emissions; Personal care | Elsevier | CPCat |
| Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care; Europe | Danish Environmental Protection Agency | Danish EPA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =3000 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 4FEX897A91 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4FEX897A91 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4FEX897A91 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4FEX897A91 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 364 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =400 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =44264.6 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =8852.93 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_TX_TCEQ |
| =19936.8 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_TX_TCEQ |
| =3658 | mg/m3 | NOAEL (HEC) | inhalation | Rat | ToxValDB_PPRTV_(CPHEA) |
| =1 | mg/m3 | RfC (provisional) | inhalation | Human | ToxValDB_PPRTV_(CPHEA) |
| =10 | mg/m3 | RfC (provisional) | inhalation | Human | ToxValDB_PPRTV_(CPHEA) |
Showing 14 of 14 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Pentane | 203-692-4 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Pentane (CAS 109-66-0) is classified under EU CLP Annex VI as Flam. Liq. 2; Asp. Tox. 1; STOT SE 3; Aquatic Chronic 2 with signal word Danger. Hazard statements: H225; H304; H336; H411. Source: EU CLP Annex VI (ECHA).
Pentane has 14 NOAEL studies in the database. The lowest reported value is 3000 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Pentane appears on 8 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, Indirect additives food contact (10/2018), air; detected; emissions; Personal care, and 5 more. Source: EPA CPDat.
Occupational exposure limits for Pentane are set by OSHA, NIOSH, ACGIH. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Pentane is also indexed as a cosmetic ingredient under the name Pentane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Pentane is classified GHS Danger (H225, H304, H336, H411) in the chemicals database but is restricted in EU cosmetics.
Pentane also appears in cosmetics, pharmaceutical, cannabis databases.