Also known as: Ethanamine, N-ethyl-, EINECS 203-716-3, Dwuetyloamina, UNII-B035PIS86W, (C2H5)2NH (+2 more)
CAS 109-89-7
Diethylamine (CAS 109-89-7) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H332; H312; H302; H314. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
Diethylamine is classified GHS Danger (H225, H332, H312, H302, H314) in the chemicals database but is restricted in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 2; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1A | H225; H332; H312; H302; H314 | GHS02; GHS07; GHS05 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Highly flammable liquid and vapour Toxic in contact with skin Harmful if swallowed or if inhaled Causes severe skin burns and eye damage May cause respiratory irritation Harmful to aquatic life |
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. Inhalation may cause pneumonitis. Exposure at high levels could cause severe swelling of the throat. Medical observation is indicated. |
| Long-term Effects | Lungs may be affected by repeated or prolongated exposure to the vapour. The substance may have effects on the teeth. This may result in erosion. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 25 ppm (75 mg/m³) | 25 | 75 | N |
| NIOSH | TWA | 10 ppm (30 mg/m³) | 10 | 30 | N |
| NIOSH | STEL | 25 ppm (75 mg/m³) | 25 | 75 | N |
| ACGIH | TWA | 5 ppm [2012] | 5 | - | Y |
| ACGIH | STEL | 15 ppm [2012] | 15 | - | Y |
| CAL/OSHA | CEILING | 5 ppm (15 mg/m³) | 5 | 15 | Y |
| NIOSH | IDLH | 200 ppm | 200 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Europe | European Commission | Fl@vis |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =17.08 | mg/m3 | BMCL (10) | inhalation | Mouse | ToxValDB TX TCEQ |
| 33 | min | Breakthrough Time | Dermal | - | NTP ICE skin irritation |
| 34 | min | Breakthrough Time | Dermal | - | NTP ICE skin irritation |
| =9.6 | mg/m3 | DNEL local | inhalation | Human | ToxValDB GESTIS DNEL |
| =15 | mg/m3 | DNEL local | inhalation | Human | ToxValDB GESTIS DNEL |
| =0.64 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 14.2 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| B035PIS86W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 11.96 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 17.04 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| =540 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =560 | mg/m3 | LEL | inhalation | Mouse | ECHA |
| =610 | mg/m3 | LEL | inhalation | Mouse | ECHA |
| =5.384e+4 | mg/m3 | LEL | inhalation | Human | ToxValDB DOE Protective Action Criteria |
| =29.91 | mg/m3 | LOAEL | inhalation | Human | ToxValDB TX TCEQ |
| =75 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB EU SCOEL |
| =76 | mg/m3 | NOAEL | inhalation | Rat | ECHA |
| 0.9 | kiloohms | TER | Dermal | - | NTP ICE skin irritation |
| 62.5 | ppm | Top dose | Inhalation | Mouse | NTP ICE cancer |
| 125 | ppm | Top dose | Inhalation | Rat | NTP ICE cancer |
Showing 21 of 21 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Diethylamine | 203-716-3 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Diethylamine (CAS 109-89-7) is classified under EU CLP Annex VI as Flam. Liq. 2; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1A with signal word Danger. Hazard statements: H225; H332; H312; H302; H314. Source: EU CLP Annex VI (ECHA).
Diethylamine has 21 NOAEL studies in the database. The lowest reported value is 0.64 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
Diethylamine appears on 6 regulatory/inventory lists including detected; Europe; Other direct contact consumer goods, inert_ingredient; non_food_use; Pesticides, pharmaceutical, and 3 more. Source: EPA CPDat.
Occupational exposure limits for Diethylamine are set by OSHA, NIOSH, ACGIH. 7 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Diethylamine is also indexed as a cosmetic ingredient under the name Diethylamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Diethylamine is classified GHS Danger (H225, H332, H312, H302, H314) in the chemicals database but is restricted in EU cosmetics.
Diethylamine also appears in cosmetics, pharmaceutical databases.