Poor Cosmetic Ingredient NOAEL Data GHS Classified

Diethylamine

INCI: DIETHYLAMINE

CAS Number
109-89-7
Function
pH adjuster / chemical intermediate (secondary amine)
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status restricted
US Notes No explicit CFR ban, but FDA advises against nitrosamine-forming ingredients in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Diethylamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 0.076 mg/L air 1991 rat inhalation REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
DANGER
Pictograms
flam;flame; corr; skull;toxic
Hazard Statements
Highly flammable liquid and vapour Toxic in contact with skin Harmful if swallowed or if inhaled Causes severe skin burns and eye damage May cause respiratory irritation Harmful to aquatic life
Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. Inhalation may cause pneumonitis. Exposure at high levels could cause severe swelling of the throat. Medical observation is indicated.
Long-term Exposure Effects
Lungs may be affected by repeated or prolongated exposure to the vapour. The substance may have effects on the teeth. This may result in erosion.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Expert Verdict

Nitrosamine precursor forming NDEA (N-nitrosodiethylamine, a potent carcinogen); corrosive to skin and eyes; flammable with flash point −28 °C; REACH Annex XVII restricted.

⚠️
Concern Level: High

Regulatory Flags

endocrine_disruptor

Frequently Asked Questions

Is Diethylamine safe in cosmetics?

Nitrosamine precursor forming NDEA (N-nitrosodiethylamine, a potent carcinogen); corrosive to skin and eyes; flammable with flash point −28 °C; REACH Annex XVII restricted. The EU classifies Diethylamine as "restricted". Safety rating: POOR. 1 toxicological study endpoint(s) are available in our database.

Is Diethylamine allowed in the EU?

Diethylamine EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Diethylamine do in cosmetics?

Diethylamine functions as: pH adjuster / chemical intermediate (secondary amine). It is classified as a cosmetic ingredient in our database. CAS number: 109-89-7.

What is the Margin of Safety for Diethylamine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Diethylamine?

The NOAEL (No Observed Adverse Effect Level) for Diethylamine is 0.076 mg/L air based on a inhalation study via 1991 route in rat. Source: REACH.

Is Diethylamine classified as hazardous under GHS?

Diethylamine carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour Toxic in contact with skin Harmful if swallowed or if inhaled Causes severe skin burns and eye damage May cause respiratory irritation Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check Diethylamine compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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