Is Diethylamine safe in cosmetics?
Diethylamine has a safety rating of "POOR" in our database. EU status: restricted. US status: restricted.
Diethylamine
Also known as: Ethanamine, N-ethyl-, EINECS 203-716-3, Dwuetyloamina, UNII-B035PIS86W, (C2H5)2NH (+2 more)
INCI: DIETHYLAMINE
Diethylamine (CAS 109-89-7) is a cosmetic cosmetic ingredient functioning as pH adjuster / chemical intermediate (secondary amine). EU Regulation 1223/2009 status: restricted; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 109-89-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Diethylamine is classified GHS Danger (H225, H301, H311, H331, H302, H312, H314, H318) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
pH adjuster / chemical intermediate (secondary amine)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
N-ethylethanamine
InChIKey
HPNMFZURTQLUMO-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
restricted
US Notes
No explicit CFR ban, but FDA advises against nitrosamine-forming ingredients in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diethylamine.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
FlamFlameCorrSkullToxic
Hazard Statements
Highly flammable liquid and vapour Toxic in contact with skin Harmful if swallowed or if inhaled Causes severe skin burns and eye damage May cause respiratory irritation Harmful to aquatic life
Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. Inhalation may cause pneumonitis. Exposure at high levels could cause severe swelling of the throat. Medical observation is indicated.
Long-term Exposure Effects
Lungs may be affected by repeated or prolongated exposure to the vapour. The substance may have effects on the teeth. This may result in erosion.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
FlammableHarmful / IrritantCorrosive
Hazard Class and Category
Flam. Liq. 2; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1A
Hazard Statements
- H225 Highly flammable liquid and vapour
- H332 Harmful if inhaled
- H312 Harmful in contact with skin
- H302 Harmful if swallowed
- H314 Causes severe skin burns and eye damage
Specific Concentration Limits / M-factors
STOT SE 3; H335: C ≥ 1.0%
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (5)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Carcinogen Classification
Diethylamine | TR-566: Toxicology and Carcinogenesis Studies of Diethylamine (CASRN 109-89-7) in F344/N Rats and B6C3F1 Mice (Inhalation studies) (2011 ) | 11/19/09 | No Evidence | No Evidence | No Evidence | No Evidence | Under the conditions of these 2-year inhalation studies, there was no evidence of carcinogenic activity of diethylamine in male or female F344/N rats exposed to 31, 62.
Source: NTP Technical Reports
Evidence for Carcinogenicity
A4: Not classifiable as a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
0444
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Diethylamine vapor is a severe irritant to mucous membranes, eyes, and skin.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
pH regulating agent
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Diethylamine.
Regulatory Flags
endocrine_disruptor
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Diethylamine by CAS number or substance name.
Studies
21
Lowest NOAEL
15 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Ethanamine, N-ethyl-
EINECS 203-716-3
Dwuetyloamina
UNII-B035PIS86W
(C2H5)2NH
DEA
Et2NH
Chemical Function
Deodorizer
Fragrance
pH regulating agent
Flavouring and nutrient
Regulatory Lists
detected; Europe; Other direct contact consumer goods
detected; Europe; Other direct contact consumer goods
inert_ingredient; non_food_use; Pesticides
pharmaceutical
Indirect additives food contact (10/2018)
air; detected; emissions; Europe; Other direct contact consumer goods
detected; Europe; Other direct contact consumer goods
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DIETHYLAMINE
ChEMBL ID
CHEMBL1189
Max Phase
3
Frequently Asked Questions
Is Diethylamine allowed in the EU?
Diethylamine EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethylamine do in cosmetics?
Diethylamine functions as: pH adjuster / chemical intermediate (secondary amine). It is classified as a cosmetic ingredient in our database. CAS number: 109-89-7.
Is Diethylamine classified as hazardous under GHS?
Diethylamine carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour Toxic in contact with skin Harmful if swallowed or if inhaled Causes severe skin burns and eye damage May cause respiratory irritation Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Diethylamine used outside cosmetics?
Diethylamine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Diethylamine have different safety status in cosmetics vs industrial chemicals?
Diethylamine is classified GHS Danger (H225, H301, H311, H331, H302, H312, H314, H318) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Diethylamine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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