NOAEL Data REACH Registered Cosmetic Ingredient

HC Yellow no. 10

Also known as: UNII-VQY3VF9106, 1,5-Di(beta-hydroxyethyl)amino-2-nitro-4-chlorobenzene, Ethanol, 2,2'-((4-chloro-6-nitro-1,3-phenylene)diimino)bis-, HC Yellow 10, Imexine FAH

CAS 109023-83-8

HC Yellow no. 10 (CAS 109023-83-8) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS, ECHA REACH.

View cosmetic safety profile for HC Yellow No. 10 →

Cross-Vertical Regulatory Divergence

HC Yellow no. 10 is prohibited in EU cosmetics at max 0.1% but has active industrial GHS classifications (H315, H319, H335).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 10 fields

Name

HC Yellow no. 10

CAS Number

109023-83-8

Molecular Formula

C10H14ClN3O4

InChI Key

ZEARLPPIUCBHRP-UHFFFAOYSA-N

Monoisotopic Mass

275.067284

Synonyms

UNII-VQY3VF91061,5-Di(beta-hydroxyethyl)amino-2-nitro-4-chlorobenzeneEthanol, 2,2'-((4-chloro-6-nitro-1,3-phenylene)diimino)bis-HC Yellow 10Imexine FAH

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 16 of 16 studies

Value	Unit	Endpoint	Route	Species	Source
100	mg/kg/day	-	-	-	Regulatory source
125	mg/kg/day	-	oral	-	Regulatory source
VQY3VF9106	UNII	FDA UNII substance identifier	-	-	openFDA substances
25	mg/kg bw/day	LOAEL	oral	rat	COSMOS DB
=0.0016	mg/kg	NOAEL	oral	rat	SCCS Opinion
=100	mg/kg/day	NOAEL	-	-	SCCS Opinion
=100	mg/kg	NOAEL	oral	rat	SCCS Opinion
=125	mg/kg/day	NOAEL	oral	-	SCCS Opinion
=500	mg/kg bw	NOAEL	oral	rat	SCCS Opinion
=2000	mg/kg	NOAEL	oral	rat	SCCS Opinion
=0.0016	mg/kg	dermal absorption	oral	rat	Regulatory source
=100	mg/kg	dermal absorption	oral	rat	Regulatory source
500	mg/kg bw	dermal absorption	oral	rat	Regulatory source
100	mg/kg/day	developmental toxicity	-	rat	Regulatory source
100	mg/kg/day	developmental toxicity	oral	rat	Regulatory source
2000	mg/kg	developmental toxicity	oral	rat	Regulatory source

Showing 16 of 16 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	1,5-Di(beta-hydroxyethyl)amino-2-nitro-4-chlorobenzene	416-940-3	ECHA overview →

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 3 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1418/10	22 March 2011	safe	0.5%	secondary amine; nitrosamine <50ppb; sensitisation not excluded
SCCP/1066/07	19 June 2007	safe	1.0%	secondary amine; nitrosamine <50ppb; sensitisation not excluded
SCCP/1080/07	2007-06-19	The SCCP is of the opinion that the use of HC Yellow n°10 itself as a semi-permanent hair dye at an on-head concentration of maximum 0.1% does not pose a risk to the health of the consumer.	0.1% (on-head)	HC Yellow n°10 is a secondary amine; should not be used in combination with nitrosating substances; nitrosamine content should be < 50 ppb.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

0.1%

Frequently Asked Questions

What is the NOAEL for HC Yellow no. 10?

HC Yellow no. 10 has 16 NOAEL studies in the database. The lowest reported value is 100 mg/kg/day. Source: Regulatory source.

What regulatory lists include HC Yellow no. 10?

HC Yellow no. 10 appears on 2 regulatory/inventory lists including Europe; Personal care; restricted, Europe; Personal care - hair coloring. Source: EPA CPDat.

Is HC Yellow no. 10 used in cosmetics?

Yes, HC Yellow no. 10 is also indexed as a cosmetic ingredient under the name HC Yellow No. 10. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for HC Yellow no. 10 come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does HC Yellow no. 10 have different safety status in cosmetics vs industrial chemicals?

HC Yellow no. 10 is prohibited in EU cosmetics at max 0.1% but has active industrial GHS classifications (H315, H319, H335).

Is HC Yellow no. 10 used outside industrial chemicals?

HC Yellow no. 10 also appears in cosmetics databases.