Is HC Yellow No. 10 safe in cosmetics?
HC Yellow No. 10 has a safety rating of "GOOD" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
HC Yellow No. 10
Also known as: UNII-VQY3VF9106, 1,5-Di(beta-hydroxyethyl)amino-2-nitro-4-chlorobenzene, Ethanol, 2,2'-((4-chloro-6-nitro-1,3-phenylene)diimino)bis-, HC Yellow 10, Imexine FAH
INCI: HC YELLOW NO. 10
HC Yellow No. 10 (CAS 109023-83-8) is a cosmetic cosmetic ingredient functioning as Semi-permanent non-oxidative hair dye, nitro dye class. Reported NOAEL =0.0016 mg/kg in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: prohibited, max 0.1%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 109023-83-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
HC Yellow No. 10 is prohibited in EU cosmetics at max 0.1% but has active industrial GHS classifications (H315, H319, H335).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Semi-permanent non-oxidative hair dye, nitro dye class
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-[4-chloro-5-(2-hydroxyethylamino)-2-nitroanilino]ethanol
InChIKey
ZEARLPPIUCBHRP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
EU Max Conc.
0.1%
US US Status
permitted
US Notes
Permitted under coal-tar hair dye exemption under FD&C Act §601(a); requires caution labeling
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for HC Yellow No. 10.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for HC Yellow No. 10. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.0016 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.0016 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.0016 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.0016 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =100 mg/kg/day | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =100 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =100 mg/kg/day | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =100 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =100 mg/kg/day | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =100 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
KR Korea MFDS Annex 2 (Restricted)
Category: Restricted. Max: 비산화염모제에 0.1%. 기타제품에는 사용금지
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in non-oxidative hair dyes products. Max: 0.001.
BRIN Brazil/India Cosmetics
India: Restricted · max 0.001
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (2 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.024% | - | - | SCCP/0101 |
| measured | 0.16% | - | - | SCCP/0101 |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "109023-83-8", "ingredient_class": "direct_dye", "chemical_class": "nitro", "molecular_weight_Da": "226.23", "color_result_on_hair": "Yellow", "shade_range": "blonde", "primary_function": "direct_deposit", "requires_developer": "no", "lift_capability_levels": "0", "deposit_only": "yes", "permanence": "semi_permanent", "wash_fastness_shampoos": "6-12", "light_fastness": "moderate", "…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for HC Yellow No. 10.
Regulatory Flags
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to HC Yellow No. 10 by CAS number or substance name.
Studies
24
Lowest NOAEL
0.0016
Highest NOAEL
2000
Units vary across source rows: mg/kg, mg/kg/day, mg/kg bw
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 0.024% | - | - |
| 0.16% | - | - |
Known Synonyms
UNII-VQY3VF9106
1,5-Di(beta-hydroxyethyl)amino-2-nitro-4-chlorobenzene
Ethanol, 2,2'-((4-chloro-6-nitro-1,3-phenylene)diimino)bis-
HC Yellow 10
Imexine FAH
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Frequently Asked Questions
Is HC Yellow No. 10 allowed in the EU?
HC Yellow No. 10 EU regulatory status: prohibited. Maximum allowed concentration: 0.1%. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Yellow No. 10 do in cosmetics?
HC Yellow No. 10 functions as: Semi-permanent non-oxidative hair dye, nitro dye class. It is classified as a cosmetic ingredient in our database. CAS number: 109023-83-8.
What is the NOAEL for HC Yellow No. 10?
The NOAEL (No Observed Adverse Effect Level) for HC Yellow No. 10 is =0.0016 mg/kg based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is HC Yellow No. 10 used outside cosmetics?
HC Yellow No. 10 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does HC Yellow No. 10 have different safety status in cosmetics vs industrial chemicals?
HC Yellow No. 10 is prohibited in EU cosmetics at max 0.1% but has active industrial GHS classifications (H315, H319, H335).
Compliance Tools
Check HC Yellow No. 10 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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