What is the NOAEL for Butanedioic acid?
Butanedioic acid has 10 NOAEL studies in the database. The lowest reported value is 10 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Butanedioic acid
Also known as: Succinic acid, 4-02-00-01908, BRN 1754069, EINECS 203-740-4, Ethylene dicarboxylic acid (+14 more)
CAS 110-15-6
Butanedioic acid (CAS 110-15-6) is a chemical substance. Key regulatory status: REACH registered, 11 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Butanedioic acid is classified GHS Danger (H318, H319) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
11
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Butanedioic acid
CAS Number
110-15-6
DTXSID
DTXSID6023602
Molecular Formula
C4H6O4
InChI Key
KDYFGRWQOYBRFD-UHFFFAOYSA-N
Monoisotopic Mass
118.026609
Synonyms
Succinic acid4-02-00-01908BRN 1754069EINECS 203-740-4Ethylene dicarboxylic acidEthylenesuccinic acidKyselina jantarovaUNII-AB6MNQ6J6LSuccinicum acidum1,2-Ethanedicarboxylate1,4-ButanedioateButandisaeure
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
12 records
DeodorizerpH regulating agentFragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
11 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =10 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| AB6MNQ6J6L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| AB6MNQ6J6L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| AB6MNQ6J6L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| AB6MNQ6J6L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =2260 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =500 | mg/kg bw/day | LOAEL | injection | Rat | ToxValDB_HPVIS |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 2500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =75.6 | mg/L | NOEL | oral | Mouse | ToxValDB_ECOTOX |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Succinic acid | 203-740-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
buffering agent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
SUCCINIC ACID
ChEMBL Phase
3
Adverse Events
2
Bioactivity
8
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
2 records
E363 — ADI: No ADI established mg/kg bw | FDA GRAS: FDA has no questions
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Butanedioic acid?
Butanedioic acid appears on 8 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, and 5 more. Source: EPA CPDat.
Is Butanedioic acid used in cosmetics?
Yes, Butanedioic acid is also indexed as a cosmetic ingredient under the name Succinic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Butanedioic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Butanedioic acid have different safety status in cosmetics vs industrial chemicals?
Butanedioic acid is classified GHS Danger (H318, H319) in the chemicals database but is allowed in EU cosmetics.
Is Butanedioic acid used outside industrial chemicals?
Butanedioic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.