Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Succinic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 2500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 2500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
Expert Verdict
Succinic Acid (CAS 110-15-6) is permitted in cosmetics under EC Regulation 1223/2009 with no Annex restrictions. US: No FDA restrictions. CIR review of dicarboxylic acids group is ongoing with draft presented June 2025. Non-sensitizing but severe eye irritant in neat form; use appropriate eye protection during handling. Endogenous metabolite with wide de facto safety margin at typical cosmetic concentrations of 0.5-2%.
Regulatory Flags
Frequently Asked Questions
Is Succinic Acid safe in cosmetics?
Succinic Acid (CAS 110-15-6) is permitted in cosmetics under EC Regulation 1223/2009 with no Annex restrictions. US: No FDA restrictions. CIR review of dicarboxylic acids group is ongoing with draft presented June 2025. Non-sensitizing but severe eye irritant in neat form; use appropriate eye protection during handling. Endogenous metabolite with wide de facto safety margin at typical cosmetic concentrations of 0.5-2%. The EU classifies Succinic Acid as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.
Is Succinic Acid allowed in the EU?
Succinic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Succinic Acid do in cosmetics?
Succinic Acid functions as: Buffering agent, pH adjuster, mild exfoliant, antimicrobial. It is classified as a cosmetic ingredient in our database. CAS number: 110-15-6.
What is the Margin of Safety for Succinic Acid?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Succinic Acid?
The NOAEL (No Observed Adverse Effect Level) for Succinic Acid is 2500 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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