What is the GHS hazard classification for N,N'-Methylenebisacrylamide?
N,N'-Methylenebisacrylamide (CAS 110-26-9) is classified under EU CLP Annex VI as Muta. 1B with signal word Danger. Hazard statements: H340. Source: EU CLP Annex VI (ECHA).
Danger
GHS08
NOAEL Data
REACH Registered
Cosmetic Ingredient
N,N'-Methylenebisacrylamide
Also known as: BRN 1706297, EINECS 203-750-9, N,N'-Methylidenebisacrylamide, UNII-EDK4RIE19C
CAS 110-26-9
N,N'-Methylenebisacrylamide (CAS 110-26-9) is a chemical substance with GHS signal word Danger; key hazard signal: H340. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for N,N'-METHYLENEBISACRYLAMIDE →
Cross-Vertical Regulatory Divergence
N,N'-Methylenebisacrylamide is classified GHS Danger (H340) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
N,N'-Methylenebisacrylamide
CAS Number
110-26-9
DTXSID
DTXSID8025595
Molecular Formula
C7H10N2O2
InChI Key
ZIUHHBKFKCYYJD-UHFFFAOYSA-N
Monoisotopic Mass
154.074228
Synonyms
BRN 1706297EINECS 203-750-9N,N'-MethylidenebisacrylamideUNII-EDK4RIE19C
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Muta. 1B | H340 | GHS08 | Danger |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
No specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 2.954 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| EDK4RIE19C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EDK4RIE19C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EDK4RIE19C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EDK4RIE19C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| =390 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =2 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | N,N'-methylenediacrylamide | 203-750-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1401480
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Frequently Asked Questions
What is the NOAEL for N,N'-Methylenebisacrylamide?
N,N'-Methylenebisacrylamide has 9 NOAEL studies in the database. The lowest reported value is 2.954 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
What regulatory lists include N,N'-Methylenebisacrylamide?
N,N'-Methylenebisacrylamide appears on 2 regulatory/inventory lists including detected; Europe; Toys and children's products, Indirect additives food contact (10/2018). Source: EPA CPDat.
Is N,N'-Methylenebisacrylamide used in cosmetics?
Yes, N,N'-Methylenebisacrylamide is also indexed as a cosmetic ingredient under the name N,N'-METHYLENEBISACRYLAMIDE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for N,N'-Methylenebisacrylamide come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does N,N'-Methylenebisacrylamide have different safety status in cosmetics vs industrial chemicals?
N,N'-Methylenebisacrylamide is classified GHS Danger (H340) in the chemicals database but is allowed in EU cosmetics.
Is N,N'-Methylenebisacrylamide used outside industrial chemicals?
N,N'-Methylenebisacrylamide also appears in cosmetics, pharmaceutical databases.