Is N,N'-METHYLENEBISACRYLAMIDE safe in cosmetics?
N,N'-METHYLENEBISACRYLAMIDE has a safety rating of "GOOD" in our database. EU status: permitted. US status: prohibited. 1 toxicological study endpoint(s) are available in our database.
N,N'-METHYLENEBISACRYLAMIDE
Also known as: BRN 1706297, EINECS 203-750-9, N,N'-Methylidenebisacrylamide, UNII-EDK4RIE19C
N,N'-METHYLENEBISACRYLAMIDE (CAS 110-26-9) is a cosmetic cosmetic ingredient functioning as Not Reported. Reported NOAEL =2 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 110-26-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
N,N'-METHYLENEBISACRYLAMIDE is classified GHS Danger (H301, H302, H312, H317, H318, H332, H340, H350) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Not Reported
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
N-[(prop-2-enoylamino)methyl]prop-2-enamide
InChIKey
ZIUHHBKFKCYYJD-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
prohibited
US Notes
Not specifically prohibited for cosmetics by FDA; however, the CMR classification under GHS/CLP makes it a significant liability; formulators should treat it as unsuitable for cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
1 study endpoint found for N,N'-METHYLENEBISACRYLAMIDE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =2 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Health Hazard
Hazard Class and Category
Muta. 1B
Hazard Statements
- H340 May cause genetic defects
Inserted via ATP: ATP22
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1762
(EU) 2026/78
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for N,N'-METHYLENEBISACRYLAMIDE.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to N,N'-METHYLENEBISACRYLAMIDE by CAS number or substance name.
Studies
1
Lowest NOAEL
2 mg/kg bw/day
Highest NOAEL
2 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
BRN 1706297
EINECS 203-750-9
N,N'-Methylidenebisacrylamide
UNII-EDK4RIE19C
Chemical Function
No specific technical function
Regulatory Lists
detected; Europe; Toys and children's products
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1401480
Frequently Asked Questions
Is N,N'-METHYLENEBISACRYLAMIDE allowed in the EU?
N,N'-METHYLENEBISACRYLAMIDE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does N,N'-METHYLENEBISACRYLAMIDE do in cosmetics?
N,N'-METHYLENEBISACRYLAMIDE functions as: Not Reported. It is classified as a cosmetic ingredient in our database. CAS number: 110-26-9.
What is the NOAEL for N,N'-METHYLENEBISACRYLAMIDE?
The NOAEL (No Observed Adverse Effect Level) for N,N'-METHYLENEBISACRYLAMIDE is =2 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is N,N'-METHYLENEBISACRYLAMIDE used outside cosmetics?
N,N'-METHYLENEBISACRYLAMIDE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does N,N'-METHYLENEBISACRYLAMIDE have different safety status in cosmetics vs industrial chemicals?
N,N'-METHYLENEBISACRYLAMIDE is classified GHS Danger (H301, H302, H312, H317, H318, H332, H340, H350) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
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MoS Calculator
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