What is the NOAEL for Dihexyl hexanedioate?
Dihexyl hexanedioate has 6 NOAEL studies in the database. The lowest reported value is H16ECG10GB UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dihexyl hexanedioate
Also known as: Hexanedioic acid, dihexyl ester, Hexanedioic acid, 1,6-dihexyl ester, BRN 1798668, EINECS 203-757-7, Plasticizer dihexyl adipate (+1 more)
CAS 110-33-8
Dihexyl hexanedioate (CAS 110-33-8) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Dihexyl hexanedioate is prohibited in EU cosmetics but has active industrial GHS classifications.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
Dihexyl hexanedioate
CAS Number
110-33-8
DTXSID
DTXSID9026841
Molecular Formula
C18H34O4
InChI Key
HHECSPXBQJHZAF-UHFFFAOYSA-N
Monoisotopic Mass
314.24571
Synonyms
Hexanedioic acid, dihexyl esterHexanedioic acid, 1,6-dihexyl esterBRN 1798668EINECS 203-757-7Plasticizer dihexyl adipateUNII-H16ECG10GB
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
SolventSoftener and conditionerPlasticizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| H16ECG10GB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H16ECG10GB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H16ECG10GB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H16ECG10GB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| >=1430 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
Showing 6 of 6 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dihexyl adipate | 203-757-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3185271
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Dihexyl hexanedioate?
Dihexyl hexanedioate appears on 1 regulatory/inventory list including Europe; plastic_additive. Source: EPA CPDat.
Is Dihexyl hexanedioate used in cosmetics?
Yes, Dihexyl hexanedioate is also indexed as a cosmetic ingredient under the name Dihexyl Adipate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dihexyl hexanedioate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Dihexyl hexanedioate have different safety status in cosmetics vs industrial chemicals?
Dihexyl hexanedioate is prohibited in EU cosmetics but has active industrial GHS classifications.
Is Dihexyl hexanedioate used outside industrial chemicals?
Dihexyl hexanedioate also appears in cosmetics, pharmaceutical databases.