Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Dihexyl Adipate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 630 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 200 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | >=1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 630 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 200 mg/kg bw/day | oral | mouse | oral | REACH |
Expert Verdict
Historically used as an industrial plasticiser; verify cosmetic-grade purity and confirm absence of industrial contaminants; limited cosmetic-specific safety data with supportable read-across from diethylhexyl adipate.
Frequently Asked Questions
Is Dihexyl Adipate safe in cosmetics?
Historically used as an industrial plasticiser; verify cosmetic-grade purity and confirm absence of industrial contaminants; limited cosmetic-specific safety data with supportable read-across from diethylhexyl adipate. The EU classifies Dihexyl Adipate as "prohibited". Safety rating: GOOD. 5 toxicological study endpoint(s) are available in our database.
Is Dihexyl Adipate allowed in the EU?
Dihexyl Adipate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihexyl Adipate do in cosmetics?
Dihexyl Adipate functions as: Emollient, plasticiser, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 110-33-8.
What is the Margin of Safety for Dihexyl Adipate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dihexyl Adipate?
The NOAEL (No Observed Adverse Effect Level) for Dihexyl Adipate is 630 mg/kg bw/day based on a oral study via oral route in rat. A total of 5 study endpoints are available. Source: REACH.
Compliance Tools
Check Dihexyl Adipate compliance across multiple jurisdictions:
Related Ingredients
Is Dihexyl Adipate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Dihexyl Adipate in your formulation.