Is Dihexyl Adipate safe in cosmetics?
Dihexyl Adipate has a safety rating of "GOOD" in our database. EU status: prohibited. US status: permitted.
Good
Cosmetic Ingredient
Dihexyl Adipate
Also known as: Hexanedioic acid, dihexyl ester, Hexanedioic acid, 1,6-dihexyl ester, BRN 1798668, EINECS 203-757-7, Plasticizer dihexyl adipate (+1 more)
INCI: DIHEXYL ADIPATE
Dihexyl Adipate (CAS 110-33-8) is a cosmetic cosmetic ingredient functioning as Emollient, plasticiser, skin conditioning. NOAEL 200 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 110-33-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Dihexyl Adipate is prohibited in EU cosmetics but has active industrial GHS classifications.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word
Function
Emollient, plasticiser, skin conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
dihexyl hexanedioate
InChIKey
HHECSPXBQJHZAF-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted — no CFR prohibition or restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dihexyl Adipate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dihexyl Adipate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Plasticizer
Softener and conditioner
Solvent
Expert Verdict
Expert safety assessment and concern-level summary for Dihexyl Adipate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dihexyl Adipate by CAS number or substance name.
Studies
18
Lowest NOAEL
178 mg/kg bw/day
Highest NOAEL
2187 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Hexanedioic acid, dihexyl ester
Hexanedioic acid, 1,6-dihexyl ester
BRN 1798668
EINECS 203-757-7
Plasticizer dihexyl adipate
UNII-H16ECG10GB
Chemical Function
Solvent
Softener and conditioner
Plasticizer
Regulatory Lists
Europe; plastic_additive
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3185271
Frequently Asked Questions
Is Dihexyl Adipate allowed in the EU?
Dihexyl Adipate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihexyl Adipate do in cosmetics?
Dihexyl Adipate functions as: Emollient, plasticiser, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 110-33-8.
Is Dihexyl Adipate used outside cosmetics?
Dihexyl Adipate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Dihexyl Adipate have different safety status in cosmetics vs industrial chemicals?
Dihexyl Adipate is prohibited in EU cosmetics but has active industrial GHS classifications.
Compliance Tools
Check Dihexyl Adipate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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