Danger GHS02GHS08GHS06 NOAEL Data SVHC Prop 65 REACH Registered Cosmetic Ingredient

2-Ethoxyethanol

Also known as: Ethylene glycol monoethyl ether, EGMEE, EINECS 203-804-1, beta-Ethoxyethanol, Ethylethylene glycol (+14 more)

CAS 110-80-5

2-Ethoxyethanol (CAS 110-80-5) is a chemical substance with GHS signal word Danger; key hazard signal: H226; H360FD; H331; H302. Key regulatory status: SVHC Candidate List, California Proposition 65, REACH registered, 17 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ECHA SVHC, CA Prop 65, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for 2-Ethoxyethanol →

Cross-Vertical Regulatory Divergence

2-Ethoxyethanol is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H360FD, H331, H302).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 24 fields

Name

2-Ethoxyethanol

CAS Number

110-80-5

Molecular Formula

C4H10O2

InChI Key

ZNQVEEAIQZEUHB-UHFFFAOYSA-N

Monoisotopic Mass

90.06808

Synonyms

Ethylene glycol monoethyl etherEGMEEEINECS 203-804-1beta-EthoxyethanolEthylethylene glycolNCI-C54853CelosolvUNII-IDK7C2HS092-Ethoxy-Ethanol2-Ethoxyethanol (cellosolve)2-ethoxyethan-1-ol2EE

Substance of Very High Concern (SVHC)

Candidate List status and reason under the ECHA REACH SVHC program.

SOURCE ECHA 1 records

Substance	Reason	Included
2-ethoxyethanol	Toxic for reproduction (Article 57c)	15-Dec-2010

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 1 records

Chemical	Toxicity Type	Cancer	Developmental	Listed
-	developmental, male	No	Yes	-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Flam. Liq. 3; Repr. 1B; Acute Tox. 3; Acute Tox. 4	H226; H360FD; H331; H302	GHS02; GHS08; GHS06	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Flammable liquid and vapour May cause damage to central nervous system and blood May damage fertility or the unborn child
Short-term Effects	The substance is mildly irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system and blood. This may result in impaired functions and metabolic acidosis. The effects may be delayed. Medical observation is indicated.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the blood and bone marrow. This may result in anaemia and lesions of blood cells. May cause toxicity to human reproduction or development.
Routes of Exposure	The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 5 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	200 ppm (740 mg/m³)	200	740	Y
NIOSH	TWA	0.5 ppm (18 mg/m³)	0.5	18	Y
ACGIH	TWA	5 ppm [1981]	5	-	Y
CAL/OSHA	TWA	5 ppm (18 mg/m³)	5	18	Y
NIOSH	IDLH	500 ppm	500	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 14 records

SolventViscosity modifierFragranceProcessing aids not otherwise specifiedNo specific technical function

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 17 records

List	Keyword	Source
Arts and crafts/Office supplies - home office - pens and markers; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Cons electronics mech appliances and machinery; Europe	Danish Environmental Protection Agency	Danish EPA
artificial_saliva; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Canada; pharmaceutical	DrugBank	DrugBank
consumer_product	P&G	Proctor & Gamble
Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; Europe	Danish Environmental Protection Agency	Danish EPA
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
children	Oregon Health Authority	State of Oregon
OEHHA Proposition 65 (3/2019)	STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY	OEHHA Proposition 65 List
children; WA Children's Safe Product Act (4/2020)	State of Washington Department of Ecology	State of Washington
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
children	Vermont Department of Health	State of Vermont
OEHHA Proposition 65 (1/2023)	California Office of Environmental Health Hazard Assessment	OEHHA Proposition 65 List
banned; Europe; Personal care	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 89 studies

Value	Unit	Endpoint	Route	Species	Source
=4.23	mg/m3	BMCL (05 HEC)	inhalation	Rabbit	ToxValDB PPRTV (CPHEA)
=33.7	mg/kg bw/day	BMDL (10)	oral	Rat	ToxValDB PPRTV (CPHEA)
15	min	Breakthrough Time	Dermal	-	NTP ICE skin irritation
240	min	Breakthrough Time	Dermal	-	NTP ICE skin irritation
SQEinhalation=960; oral=750	ug/day	California Proposition 65 MADL	-	-	California Proposition 65
SQEdevelopmental, male	listing type	California Proposition 65 listing	-	-	California Proposition 65
=0.083	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
IDK7C2HS09	UNII	FDA UNII substance identifier	-	-	openFDA substances
7.36	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
7.367	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
>14.73	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
=1519	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=1746	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=2125	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=3460	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=5500	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=109	mg/kg bw/day	LEL	oral	Rat	ToxValDB ToxRefDB
=109	mg/kg bw/day	LEL	oral	rat (fischer; Fischer 344)	EPA ToxRefDB v3
=122	mg/kg bw/day	LEL	oral	rat (fischer; Fischer 344)	EPA ToxRefDB v3
=500	mg/kg bw/day	LEL	oral	Rat	ToxValDB ToxRefDB
=500	mg/kg bw/day	LEL	oral	rat (fischer; Fischer 344)	EPA ToxRefDB v3
=722	mg/kg bw/day	LEL	oral	Mouse	ToxValDB ToxRefDB
=722	mg/kg bw/day	LEL	oral	mouse (b6c3f1; B6C3F1)	EPA ToxRefDB v3
=804	mg/kg bw/day	LEL	oral	Rat	ToxValDB ToxRefDB
=804	mg/kg bw/day	LEL	oral	rat (fischer; Fischer 344)	EPA ToxRefDB v3
=2000	mg/kg bw/day	LEL	oral	Mouse	ToxValDB ToxRefDB
=2000	mg/kg bw/day	LEL	oral	mouse (b6c3f1; B6C3F1)	EPA ToxRefDB v3
=2725	mg/kg bw/day	LEL	oral	Mouse	ToxValDB ToxRefDB
=2725	mg/kg bw/day	LEL	oral	mouse (b6c3f1; B6C3F1)	EPA ToxRefDB v3
=5123	mg/kg bw/day	LEL	oral	Mouse	ToxValDB ToxRefDB
=5123	mg/kg bw/day	LEL	oral	mouse (b6c3f1; B6C3F1)	EPA ToxRefDB v3
=6.266e+4	mg/m3	LEL	inhalation	Human	ToxValDB DOE Protective Action Criteria
=792	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB ToxRefDB
=792	mg/kg bw/day	LOAEL	oral	rat (fischer; Fischer 344)	EPA ToxRefDB v3
=1485	mg/m3	LOAEL	inhalation	Rabbit	ToxValDB IRIS
=7255	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB ToxRefDB
=7255	mg/kg bw/day	LOAEL	oral	mouse (b6c3f1; B6C3F1)	EPA ToxRefDB v3
=265	mg/m3	LOAEL (ADJ)	inhalation	Rabbit	ToxValDB IRIS
=3605	mg/kg bw/day	LOEL	oral	Mouse	ToxValDB ECOTOX
0	unitless	Model Score	-	-	NTP ICE endocrine
>0	mg/kg bw/day	NEL	oral	rat (fischer; Fischer 344)	EPA ToxRefDB v3
=466	mg/kg bw/day	NEL	oral	Rat	ToxValDB ToxRefDB
=466	mg/kg bw/day	NEL	oral	rat (fischer; Fischer 344)	EPA ToxRefDB v3
=500	mg/kg bw/day	NEL	oral	Mouse	ToxValDB ToxRefDB
=500	mg/kg bw/day	NEL	oral	mouse (b6c3f1; B6C3F1)	EPA ToxRefDB v3
=1000	mg/kg bw/day	NEL	oral	Mouse	ToxValDB ToxRefDB
=1000	mg/kg bw/day	NEL	oral	mouse (b6c3f1; B6C3F1)	EPA ToxRefDB v3
=1304	mg/kg bw/day	NEL	oral	Mouse	ToxValDB ToxRefDB
=1304	mg/kg bw/day	NEL	oral	mouse (b6c3f1; B6C3F1)	EPA ToxRefDB v3
=2003	mg/kg bw/day	NEL	oral	Mouse	ToxValDB ToxRefDB

Showing 50 of 89 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	2-ethoxyethanol	203-804-1	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 2 records

Chemical	Category	Flags
2-Ethoxyethanol	-	-
2-Ethoxyethanol (EGEE)	N230 - Certain Glycol Ethers	-

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed 2-ETHOXYETHANOL

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 1 records

1 food-safety record found.

View full food safety profile →

Frequently Asked Questions

What is the GHS hazard classification for 2-Ethoxyethanol?

2-Ethoxyethanol (CAS 110-80-5) is classified under EU CLP Annex VI as Flam. Liq. 3; Repr. 1B; Acute Tox. 3; Acute Tox. 4 with signal word Danger. Hazard statements: H226; H360FD; H331; H302. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 2-Ethoxyethanol?

2-Ethoxyethanol has 89 NOAEL studies in the database. The lowest reported value is 0.04 mg/m3 via inhalation in Human. Source: ToxValDB PPRTV (CPHEA).

What regulatory lists include 2-Ethoxyethanol?

2-Ethoxyethanol appears on 14 regulatory/inventory lists including Arts and crafts/Office supplies - home office - pens and markers; detected; Europe, Cons electronics mech appliances and machinery; Europe, artificial_saliva; detected; emissions; Europe; Toys and children's products, and 11 more. Source: EPA CPDat.

Is 2-Ethoxyethanol on the California Proposition 65 list?

Yes, 2-Ethoxyethanol is listed under California Proposition 65 for developmental, male. Source: California OEHHA Proposition 65.

Is 2-Ethoxyethanol a Substance of Very High Concern (SVHC)?

Yes, 2-Ethoxyethanol is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Toxic for reproduction (Article 57c). Source: ECHA SVHC Candidate List.

What are the occupational exposure limits for 2-Ethoxyethanol?

Occupational exposure limits for 2-Ethoxyethanol are set by OSHA, NIOSH, ACGIH. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 2-Ethoxyethanol used in cosmetics?

Yes, 2-Ethoxyethanol is also indexed as a cosmetic ingredient under the name 2-Ethoxyethanol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Ethoxyethanol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ECHA SVHC Candidate List, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Ethoxyethanol have different safety status in cosmetics vs industrial chemicals?

2-Ethoxyethanol is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H360FD, H331, H302).

Is 2-Ethoxyethanol used outside industrial chemicals?

2-Ethoxyethanol also appears in cosmetics, pharmaceutical, food safety databases.