Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for 2-Ethoxyethanol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 185.8 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 185.8 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 1890 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 800 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| NOAEL | 3750 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| NOAEL | 3605 mg/kg bw/day | oral | mouse | Reproductive | COSMOS_DB |
| NOAEL | 1500 mg/kg bw/day | oral | mouse | Reproductive | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Hard prohibition under EU Regulation (EC) No 1223/2009 Annex II as CMR Category 2 reproductive toxicant; also prohibited in Canada and ruled unsafe by CIR in the US; do not use under any circumstances.
Regulatory Flags
Frequently Asked Questions
Is 2-Ethoxyethanol safe in cosmetics?
Hard prohibition under EU Regulation (EC) No 1223/2009 Annex II as CMR Category 2 reproductive toxicant; also prohibited in Canada and ruled unsafe by CIR in the US; do not use under any circumstances. The EU classifies 2-Ethoxyethanol as "prohibited". Safety rating: POOR. 10 toxicological study endpoint(s) are available in our database.
Is 2-Ethoxyethanol allowed in the EU?
2-Ethoxyethanol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Ethoxyethanol do in cosmetics?
2-Ethoxyethanol functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 110-80-5.
What is the Margin of Safety for 2-Ethoxyethanol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 2-Ethoxyethanol?
The NOAEL (No Observed Adverse Effect Level) for 2-Ethoxyethanol is 185.8 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Is 2-Ethoxyethanol classified as hazardous under GHS?
2-Ethoxyethanol carries a GHS signal word of "DANGER". Hazard statements: Flammable liquid and vapour May cause damage to central nervous system and blood May damage fertility or the unborn child. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
Check 2-Ethoxyethanol compliance across multiple jurisdictions:
Related Ingredients
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