NOAEL Data Cosmetic Ingredient

5-Amino-4-chloro-o-cresol hydrochloride

Also known as: 2-Methyl-4-chloro-5-aminophenol hydrochloride, Phenol, 5-amino-4-chloro-2-methyl-, hydrochloride (1:1), UNII-31J4UQW59L

CAS 110102-85-7

5-Amino-4-chloro-o-cresol hydrochloride (CAS 110102-85-7) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS.

View cosmetic safety profile for 5-Amino-4-Chloro-o-Cresol HCl →

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 8 fields

Name

5-Amino-4-chloro-o-cresol hydrochloride

CAS Number

110102-85-7

Molecular Formula

C7H8ClNO.ClH

InChI Key

KPBXDJZVHWRFLV-UHFFFAOYSA-N

Monoisotopic Mass

193.006119

Synonyms

2-Methyl-4-chloro-5-aminophenol hydrochloridePhenol, 5-amino-4-chloro-2-methyl-, hydrochloride (1:1)UNII-31J4UQW59L

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 14 of 14 studies

Value	Unit	Endpoint	Route	Species	Source
31J4UQW59L	UNII	FDA UNII substance identifier	-	-	openFDA substances
=0.19	mg/kg	NOAEL	oral	rat	SCCS Opinion
180	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
=180	mg/kg bw/day	NOAEL	-	rat	SCCS Opinion
=180	mg/kg bw	NOAEL	oral	rat	SCCS Opinion
=180	mg/kg bw/day	NOAEL	dermal	rabbit	SCCNFP Opinion
=500	mg/kg bw/day	NOAEL	oral	human	SCCS Opinion
=0.19	mg/kg	dermal absorption	oral	rat	Regulatory source
=180	mg/kg bw	dermal absorption	oral	rat	Regulatory source
500	mg/kg bw/day	developmental toxicity	oral	human	Regulatory source
180	mg/kg bw/day	genotoxicity	-	rat	Regulatory source
180	mg/kg bw/day	irritation	-	rat	Regulatory source
180	mg/kg bw/day	repeated dose toxicity	dermal	rabbit	Regulatory source
180	mg/kg bw/day	repeated dose toxicity	-	rat	Regulatory source

Showing 14 of 14 studies

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 4 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1483/12	11 December 2012	safe with restrictions	1.0% oxidative / 0.5% non-oxidative	sensitisation potential cannot be excluded
SCCS/1387/10	8 December 2009	safe with restrictions	1.0% oxidative / 0.5% non-oxidative	sensitisation not excluded; purity specifications required
SCCP/1120/07	18 December 2007	safe	1.0%	secondary amine; nitrosamine <50ppb; sensitisation not excluded
SCCP/1111/07	18 December 2007	insufficient data	-	genotoxicity in vitro positive; further in vivo data required

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

1.5%

Frequently Asked Questions

What is the NOAEL for 5-Amino-4-chloro-o-cresol hydrochloride?

5-Amino-4-chloro-o-cresol hydrochloride has 14 NOAEL studies in the database. The lowest reported value is 31J4UQW59L UNII. Source: openFDA substances.

What regulatory lists include 5-Amino-4-chloro-o-cresol hydrochloride?

5-Amino-4-chloro-o-cresol hydrochloride appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.

Is 5-Amino-4-chloro-o-cresol hydrochloride used in cosmetics?

Yes, 5-Amino-4-chloro-o-cresol hydrochloride is also indexed as a cosmetic ingredient under the name 5-Amino-4-Chloro-o-Cresol HCl. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 5-Amino-4-chloro-o-cresol hydrochloride come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 5-Amino-4-chloro-o-cresol hydrochloride used outside industrial chemicals?

5-Amino-4-chloro-o-cresol hydrochloride also appears in cosmetics databases.