5-Amino-4-Chloro-o-Cresol HCl
INCI: 5-AMINO-4-CHLORO-O-CRESOL HCL
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for 5-Amino-4-Chloro-o-Cresol HCl. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 180 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Mutagenic in Ames TA98 with S9 activation; positive in vitro micronucleus (V79 cells, dose-dependent); negative in vivo micronucleus (500 mg/kg IP); undiluted is extremely irritating to eyes
Regulatory Flags
Frequently Asked Questions
Is 5-Amino-4-Chloro-o-Cresol HCl safe in cosmetics?
Mutagenic in Ames TA98 with S9 activation; positive in vitro micronucleus (V79 cells, dose-dependent); negative in vivo micronucleus (500 mg/kg IP); undiluted is extremely irritating to eyes The EU classifies 5-Amino-4-Chloro-o-Cresol HCl as "prohibited". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.
Is 5-Amino-4-Chloro-o-Cresol HCl allowed in the EU?
5-Amino-4-Chloro-o-Cresol HCl EU regulatory status: prohibited. Maximum allowed concentration: 1.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does 5-Amino-4-Chloro-o-Cresol HCl do in cosmetics?
5-Amino-4-Chloro-o-Cresol HCl functions as: Hair colorant (oxidative hair dye precursor; reacts with primary intermediates to form hair-reactive dye). It is classified as a cosmetic ingredient in our database. CAS number: 110102-85-7.
What is the Margin of Safety for 5-Amino-4-Chloro-o-Cresol HCl?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 5-Amino-4-Chloro-o-Cresol HCl?
The NOAEL (No Observed Adverse Effect Level) for 5-Amino-4-Chloro-o-Cresol HCl is 180 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.
Compliance Tools
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