Is 5-Amino-4-Chloro-o-Cresol HCl safe in cosmetics?
5-Amino-4-Chloro-o-Cresol HCl has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
5-Amino-4-Chloro-o-Cresol HCl
Also known as: 2-Methyl-4-chloro-5-aminophenol hydrochloride, Phenol, 5-amino-4-chloro-2-methyl-, hydrochloride (1:1), UNII-31J4UQW59L
INCI: 5-AMINO-4-CHLORO-O-CRESOL HCL
5-Amino-4-Chloro-o-Cresol HCl (CAS 110102-85-7) is a cosmetic cosmetic ingredient functioning as Hair colorant (oxidative hair dye precursor; reacts with primary intermediates. Reported NOAEL =180 mg/kg bw/day in rabbit (SCCNFP_vision_codex); EU Regulation 1223/2009 status: prohibited, max 1.5%. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 110102-85-7 →
Auto-generated CPSR Part A draft with source citations
Function
Hair colorant (oxidative hair dye precursor; reacts with primary intermediates to form hair-reactive dye)
Safety Rating
MODERATE
Regulatory Status
EU EU Status
prohibited
EU Max Conc.
1.5%
US US Status
permitted
US Notes
CIR concluded safe for oxidative hair dyes (Dec 2023); coal tar hair dye exemption applies
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 5-Amino-4-Chloro-o-Cresol HCl.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for 5-Amino-4-Chloro-o-Cresol HCl. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =180 mg/kg bw/day | dermal | rabbit | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =180 mg/kg bw/day | dermal | rabbit | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =180 mg/kg bw/day | dermal | rabbit | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =180 mg/kg bw/day | dermal | rabbit | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =0.19 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.19 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.19 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.19 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =180 mg/kg bw/day | - | rat | genotoxicity | SCCS_vision_codex |
| NOAEL | =180 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in oxidative hair dye products.
BRIN Brazil/India Cosmetics
India: Restricted
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (1 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 5.29% | - | - | SCCP/0115 |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 5-Amino-4-Chloro-o-Cresol HCl.
Regulatory Flags
colorant
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 5-Amino-4-Chloro-o-Cresol HCl by CAS number or substance name.
Studies
20
Lowest NOAEL
0.19
Highest NOAEL
500
Units vary across source rows: mg/kg bw/day, mg/kg, mg/kg bw
SCCS_vision_codex
SCCNFP_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 5.29% | - | - |
Known Synonyms
2-Methyl-4-chloro-5-aminophenol hydrochloride
Phenol, 5-amino-4-chloro-2-methyl-, hydrochloride (1:1)
UNII-31J4UQW59L
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Frequently Asked Questions
Is 5-Amino-4-Chloro-o-Cresol HCl allowed in the EU?
5-Amino-4-Chloro-o-Cresol HCl EU regulatory status: prohibited. Maximum allowed concentration: 1.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does 5-Amino-4-Chloro-o-Cresol HCl do in cosmetics?
5-Amino-4-Chloro-o-Cresol HCl functions as: Hair colorant (oxidative hair dye precursor; reacts with primary intermediates to form hair-reactive dye). It is classified as a cosmetic ingredient in our database. CAS number: 110102-85-7.
What is the NOAEL for 5-Amino-4-Chloro-o-Cresol HCl?
The NOAEL (No Observed Adverse Effect Level) for 5-Amino-4-Chloro-o-Cresol HCl is =180 mg/kg bw/day based on a repeated dose toxicity study via dermal route in rabbit. A total of 10 study endpoints are available. Source: SCCNFP_vision_codex.
Compliance Tools
Check 5-Amino-4-Chloro-o-Cresol HCl compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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