What is the GHS hazard classification for 1-Hexanol?
1-Hexanol (CAS 111-27-3) is classified under EU CLP Annex VI as Acute Tox. 4 * with signal word Warning. Hazard statements: H302. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
1-Hexanol
Also known as: hexyl alcohol, 4-01-00-01694, BRN 0969167, Caswell No. 482E, EINECS 203-852-3 (+15 more)
CAS 111-27-3
1-Hexanol (CAS 111-27-3) is a chemical substance with GHS signal word Warning; key hazard signal: H302. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
NOAEL studies
NOAEL studies
40
SOURCE
Chemical inventory jurisdictions
Regulatory lists
7
SOURCE
EU CLP Annex VI
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
1-Hexanol
CAS Number
111-27-3
Molecular Formula
C6H14O
InChI Key
ZSIAUFGUXNUGDI-UHFFFAOYSA-N
Monoisotopic Mass
102.104465
Synonyms
hexyl alcohol4-01-00-01694BRN 0969167Caswell No. 482EEINECS 203-852-3EPA Pesticide Chemical Code 079047FEMA No. 2567FEMA Number 2567UNII-6CP2QER8GSAlcohol(C6)BHLC6 alcohol
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 * | H302 | GHS07 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the respiratory tract and skin. The substance is severely irritating to the eyes. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
33 records
SolventSurfactant (surface active agent)Solubility enhancerFragranceDefoamerNo specific technical functionFlavouring and nutrientPlasticizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Europe | European Commission | Fl@vis |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 40 of 40 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =210 | mg/m3 | DNEL local | inhalation | Human | ToxValDB GESTIS DNEL |
| =99 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 64.8 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP ICE eye irritation |
| 2 | unitless | EPA Classification | Ocular | Rabbit | NTP ICE eye irritation |
| 6CP2QER8GS | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 648 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 0.33 | %/sec | Intensity | Ocular | - | NTP ICE eye irritation |
| =720 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =3210 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =4420 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =4590 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =4870 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| >1500 | mg/m3 | LEL | inhalation | Rat | ECHA |
| =3000 | mg/kg bw/day | LEL | oral | Rat | ECHA |
| =5.015e+4 | mg/m3 | LEL | inhalation | Human | ToxValDB DOE Protective Action Criteria |
| =1 | % diet | LOAEL | oral | Dog | ToxValDB HPVIS |
| =1000 | mg/kg bw/day | LOAEL | oral | Dog | ECHA |
| 0 | s | Lag time | Ocular | - | NTP ICE eye irritation |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| =3500 | mg/m3 | NOAEC | inhalation | Rat | ECHA |
| >=1.580e+5 | mg/m3 | NOAEC | inhalation | Rat | ECHA |
| >0.5 | % diet | NOAEL | oral | Dog | ToxValDB HPVIS |
| =130 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =200 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| >370 | mg/kg bw/day | NOAEL | oral | Dog | ECHA |
| <435 | mg/kg bw/day | NOAEL | oral | Dog | ECHA |
| 1000 | mg/kg bw/day | NOAEL | oral | dog | COSMOS DB |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| 1022 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 1127 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =1127 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =1243 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| >3500 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB HPVIS |
| 59 | % | Plateau level | Ocular | - | NTP ICE eye irritation |
| 16.9 | % | Positive reaction | Dermal | Human | NTP ICE skin irritation |
| 28.6 | % | Positive reaction | Dermal | Human | NTP ICE skin irritation |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
| 2.3 | kiloohms | TER | Dermal | - | NTP ICE skin irritation |
| 3.6 | kiloohms | TER | Dermal | - | NTP ICE skin irritation |
Showing 40 of 40 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Hexan-1-ol | 203-852-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
1-HEXANOL
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for 1-Hexanol?
1-Hexanol has 40 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.
What regulatory lists include 1-Hexanol?
1-Hexanol appears on 7 regulatory/inventory lists including inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, Europe, and 4 more. Source: EPA CPDat.
Is 1-Hexanol used in cosmetics?
Yes, 1-Hexanol is also indexed as a cosmetic ingredient under the name Hexyl Alcohol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1-Hexanol come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 1-Hexanol used outside industrial chemicals?
1-Hexanol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.