Excellent Cosmetic Ingredient NOAEL Data GHS Classified

Hexyl Alcohol

INCI: HEXYL ALCOHOL

CAS Number
111-27-3
Function
Fragrance ingredient, solvent
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — FDA GRAS (food); no cosmetic-specific restriction under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

8 study endpoints found for Hexyl Alcohol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1022 mg/kg bw/day oral rat Special Toxicology Study COSMOS_DB
NOAEL 1000 mg/kg bw/day oral dog Subchronic COSMOS_DB
NOAEL 1127 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 1 % oral rat Subchronic COSMOS_DB
NOAEL 0.5 mg/kg bw/day oral dog Subchronic COSMOS_DB
LOAEL 1 mg/kg bw/day oral dog Subchronic COSMOS_DB
dose_tested 1022 mg/kg bw/day oral rat Special Toxicology Study COSMOS_DB
dose_tested 1127 mg/kg bw/day oral rat Subchronic COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the respiratory tract and skin. The substance is severely irritating to the eyes. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation and by ingestion.

Expert Verdict

Flammable liquid with H226 classification; causes serious eye irritation (H319) and is harmful if swallowed or in contact with skin (H302+H312). High dermal absorption requires concentration limits respecting systemic exposure calculations. Not genotoxic.

⚠️
Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Hexyl Alcohol safe in cosmetics?

Flammable liquid with H226 classification; causes serious eye irritation (H319) and is harmful if swallowed or in contact with skin (H302+H312). High dermal absorption requires concentration limits respecting systemic exposure calculations. Not genotoxic. The EU classifies Hexyl Alcohol as "permitted". Safety rating: EXCELLENT. 8 toxicological study endpoint(s) are available in our database.

Is Hexyl Alcohol allowed in the EU?

Hexyl Alcohol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hexyl Alcohol do in cosmetics?

Hexyl Alcohol functions as: Fragrance ingredient, solvent. It is classified as a cosmetic ingredient in our database. CAS number: 111-27-3.

What is the Margin of Safety for Hexyl Alcohol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Hexyl Alcohol?

The NOAEL (No Observed Adverse Effect Level) for Hexyl Alcohol is 1022 mg/kg bw/day based on a Special Toxicology Study study via oral route in rat. A total of 8 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Hexyl Alcohol compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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