Also known as: 1,2-Ethanediamine, N-(2-aminoethyl)-, 4-04-00-01238, Aminoethylethandiamine, Barsamide 115, Bis(beta-aminoethyl)amine (+7 more)
CAS 111-40-0
Diethylenetriamine (CAS 111-40-0) is a chemical substance with GHS signal word Danger; key hazard signal: H312; H302; H314; H317. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
View cosmetic safety profile for Diethylenetriamine (DETA) →
Diethylenetriamine is classified GHS Danger (H312, H302, H314, H317) in the chemicals database but is restricted in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B; Skin Sens. 1 | H312; H302; H314; H317 | GHS07; GHS05 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Fatal if inhaled Harmful if swallowed or in contact with skin Causes severe skin burns and eye damage May cause an allergic skin reaction |
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. The effects may be delayed. Medical observation is indicated. See Notes. |
| Long-term Effects | Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | CEILING | 10 ppm (42 mg/m³) (Construction and Maritime only) | 10 | 42 | Y |
| NIOSH | TWA | 1 ppm (4 mg/m³) | 1 | 4 | Y |
| ACGIH | TWA | 1 ppm [1985] | 1 | - | Y |
| CAL/OSHA | TWA | 1 ppm (4 mg/m³) | 1 | 4 | Y |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Cons electronics mech appliances and machinery; Europe | Danish Environmental Protection Agency | Danish EPA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 34 | min | Breakthrough Time | Dermal | - | NTP ICE skin irritation |
| 1222 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 2.003 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| 0.5952 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 0.4762 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| =0.87 | mg/m3 | DNEL local | inhalation | Human | ToxValDB GESTIS DNEL |
| =15.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 5.7 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 2.3 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 1259 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 3.3 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 03K6SX4V2J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.9678 | fraction | Fu | - | Human | NTP ICE adme parameters |
| >2000 | uM | IC50 | Dermal | - | NTP ICE skin sensitization |
| 1.49 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| 84 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 6207 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 369.5 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 295.6 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP ICE skin sensitization |
| =70 | mg/m3 | LEL | inhalation | Rat | ECHA |
| =8.439e+4 | mg/m3 | LEL | inhalation | Human | ToxValDB DOE Protective Action Criteria |
| >=530 | mg/kg bw/day | LOAEL | oral | Rat | ECHA |
| <=620 | mg/kg bw/day | LOAEL | oral | Rat | ECHA |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| =30 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| >=70 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| <=80 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =550 | mg/m3 | NOEC | inhalation | Rat | ECHA |
| =100 | mg/kg bw/day | NOEL | oral | Rat | ECHA |
| <=300 | mg/kg bw/day | NOEL | oral | Rat | ECHA |
| 1 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 32 of 32 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,2'-iminodi(ethylamine) | 203-865-4 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Diethylenetriamine (CAS 111-40-0) is classified under EU CLP Annex VI as Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B; Skin Sens. 1 with signal word Danger. Hazard statements: H312; H302; H314; H317. Source: EU CLP Annex VI (ECHA).
Diethylenetriamine has 32 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.
Diethylenetriamine appears on 4 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, inert_ingredient; non_food_use; Pesticides, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Occupational exposure limits for Diethylenetriamine are set by OSHA, NIOSH, ACGIH. 4 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Diethylenetriamine is also indexed as a cosmetic ingredient under the name Diethylenetriamine (DETA). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Diethylenetriamine is classified GHS Danger (H312, H302, H314, H317) in the chemicals database but is restricted in EU cosmetics.
Diethylenetriamine also appears in cosmetics, pharmaceutical databases.