Poor Cosmetic Ingredient GHS Classified

Diethylenetriamine (DETA)

INCI: DIETHYLENETRIAMINE

CAS Number
111-40-0
Function
Chelating, buffering agent; rarely used directly in finished cosmetics
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status restricted
US Notes Not specifically prohibited by CFR, but OSHA/GHS classification as corrosive effectively limits cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
DANGER
Pictograms
skull;toxic; corr
Hazard Statements
Fatal if inhaled Harmful if swallowed or in contact with skin Causes severe skin burns and eye damage May cause an allergic skin reaction
Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. The effects may be delayed. Medical observation is indicated. See Notes.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Expert Verdict

Corrosive to skin and eyes with strong sensitization potential and acute inhalation toxicity; reproductive toxicity data gaps present; unsuitable for leave-on cosmetics; if present in formulation, only acceptable as trace residual from polymer synthesis with strict ppm limits.

⚠️
Concern Level: High

Regulatory Flags

fda_food_additive

Frequently Asked Questions

Is Diethylenetriamine (DETA) safe in cosmetics?

Corrosive to skin and eyes with strong sensitization potential and acute inhalation toxicity; reproductive toxicity data gaps present; unsuitable for leave-on cosmetics; if present in formulation, only acceptable as trace residual from polymer synthesis with strict ppm limits. The EU classifies Diethylenetriamine (DETA) as "restricted". Safety rating: POOR.

Is Diethylenetriamine (DETA) allowed in the EU?

Diethylenetriamine (DETA) EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Diethylenetriamine (DETA) do in cosmetics?

Diethylenetriamine (DETA) functions as: Chelating, buffering agent; rarely used directly in finished cosmetics. It is classified as a cosmetic ingredient in our database. CAS number: 111-40-0.

What is the Margin of Safety for Diethylenetriamine (DETA)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Is Diethylenetriamine (DETA) classified as hazardous under GHS?

Diethylenetriamine (DETA) carries a GHS signal word of "DANGER". Hazard statements: Fatal if inhaled Harmful if swallowed or in contact with skin Causes severe skin burns and eye damage May cause an allergic skin reaction. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check Diethylenetriamine (DETA) compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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