Poor Cosmetic Ingredient NOAEL Data GHS Classified

Diethylenetriamine (DETA)

Also known as: 1,2-Ethanediamine, N-(2-aminoethyl)-, 4-04-00-01238, Aminoethylethandiamine, Barsamide 115, Bis(beta-aminoethyl)amine (+7 more)

INCI: DIETHYLENETRIAMINE

Diethylenetriamine (DETA) (CAS 111-40-0) is a cosmetic cosmetic ingredient functioning as Chelating, buffering agent; rarely used directly in finished cosmetics. Reported NOAEL =30 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: restricted; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.

View industrial chemical safety profile for CAS 111-40-0 →

Auto-generated CPSR Part A draft with source citations

Cross-Vertical Regulatory Divergence

Diethylenetriamine (DETA) is classified GHS Danger (H302, H312, H314, H317, H318, H330, H335, H334) in the chemicals database but is restricted in EU cosmetics.

Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

CAS Number

111-40-0

View industrial chemical safety profile →

Function

Chelating, buffering agent; rarely used directly in finished cosmetics

Safety Rating

POOR

Chemistry & Identifiers

Formula

C4H13N3

103.17 g/mol

EC Number

203-865-4

PubChem CID

8111

IUPAC Name

N'-(2-aminoethyl)ethane-1,2-diamine

InChIKey

RPNUMPOLZDHAAY-UHFFFAOYSA-N

ChEBI: CHEBI:30629 UNII: 03K6SX4V2J Wikidata: Q416728

Regulatory Status

EU EU Status restricted

US US Status restricted

US Notes Not specifically prohibited by CFR, but OSHA/GHS classification as corrosive effectively limits cosmetic use

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Diethylenetriamine (DETA).

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Diethylenetriamine (DETA). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	=30 mg/kg bw/day	oral	Rat	developmental	ToxValDB_ECHA_IUCLID
NOAEL	=100 mg/kg bw/day	oral	Rat	reproduction developmental	ToxValDB_ECHA_IUCLID

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

DANGER

Pictograms

SkullToxicCorr

Hazard Statements

Fatal if inhaled Harmful if swallowed or in contact with skin Causes severe skin burns and eye damage May cause an allergic skin reaction

Short-term Exposure Effects

The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. The effects may be delayed. Medical observation is indicated. See Notes.

Long-term Exposure Effects

Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization.

Routes of Exposure

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

EU CLP Annex VI Harmonized Classification

Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.

Signal Word

Danger

Pictograms

Harmful / IrritantCorrosive

Hazard Class and Category

Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B; Skin Sens. 1

Hazard Statements

H312 Harmful in contact with skin
H302 Harmful if swallowed
H314 Causes severe skin burns and eye damage
H317 May cause an allergic skin reaction

Inserted via ATP: CLP00

Sensitization AOP Dashboard

Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.

DPRA Cys %

5.7%

DPRA Lys %

2.3%

KeratinoSens IC50

2000 µM

LLNA EC3

NESIL

6207 µg/cm²

LLNA: Moderate (1B) GHS: 1B Human: positive

Source: LLNA: Gerberick et al. (2005); DPRA: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008]; KS: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008]; HPPT: [27] Kligman AM (1966): https://doi.org/10.1038/jid.1966.160

HRIPT Human Patch Test Studies

2 human repeat insult patch tests aggregated from dermatological literature.

Test Type	N	Sensitized	Dose µg/cm²	NESIL µg/cm²	Potency
HMT	-	0	6206.9	-	-
OECD_DA_Human	-	0	-	-	1A (Strong sensitizer)

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type

Full

Tonnage Band

10,000 - 100,000 tonnes

Substance Type

SUBSTANCE

SVHC Candidate

Hazard classification: Restricted (Annex XVII)

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Safety (3)

Carcinogen Classification

No indication of carcinogenicity to humans (not listed by IARC).

Source: Toxin and Toxin Target Database (T3DB)

ICSC Safety Card

0620

Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Skin Eye Respiratory Irritation

Diethylenetriamine ... is a skin, eye, and respiratory irritant.

Source: Hazardous Substances Data Bank (HSDB)

Function Categories & List Membership

Cosmetic/Chemical Function Categories

Adhesion/cohesion promoter Chelating agent Chemical reaction regulator Corrosion inhibitor Hardener No specific technical function Processing aids not otherwise specified

Regulatory List Membership (1)

FDA Substances Added to Food (EAFUS)

Expert Verdict

Expert safety assessment and concern-level summary for Diethylenetriamine (DETA).

Regulatory Flags

fda_food_additive

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Diethylenetriamine (DETA) by CAS number or substance name.

Studies

Lowest NOAEL

30 mg/kg bw/day

Highest NOAEL

100 mg/kg bw/day

ToxValDB_ECHA_IUCLID

Known Synonyms

1,2-Ethanediamine, N-(2-aminoethyl)- 4-04-00-01238 Aminoethylethandiamine Barsamide 115 Bis(beta-aminoethyl)amine BRN 0605314 Diethylamine, 2,2'-diamino- EINECS 203-865-4 Ethylamine, 2,2'-iminobis- Imino-bis-ethylamine UNII-03K6SX4V2J dien

Chemical Function

Hardener

Regulatory Lists

drinking_water; Europe; manufacturing; plastic_additive inert_ingredient; non_food_use; Pesticides food_additive; Substances Added to Food (formerly EAFUS) (2/2019) Cons electronics mech appliances and machinery; Europe

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

ChEMBL ID

CHEMBL303429

View full pharmaceutical profile →

Frequently Asked Questions

Is Diethylenetriamine (DETA) safe in cosmetics?

Diethylenetriamine (DETA) has a safety rating of "POOR" in our database. EU status: restricted. US status: restricted. 2 toxicological study endpoint(s) are available in our database.

Is Diethylenetriamine (DETA) allowed in the EU?

Diethylenetriamine (DETA) EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Diethylenetriamine (DETA) do in cosmetics?

Diethylenetriamine (DETA) functions as: Chelating, buffering agent; rarely used directly in finished cosmetics. It is classified as a cosmetic ingredient in our database. CAS number: 111-40-0.

What is the NOAEL for Diethylenetriamine (DETA)?

The NOAEL (No Observed Adverse Effect Level) for Diethylenetriamine (DETA) is =30 mg/kg bw/day based on a developmental study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.

Is Diethylenetriamine (DETA) classified as hazardous under GHS?

Diethylenetriamine (DETA) carries a GHS signal word of "DANGER". Hazard statements: Fatal if inhaled Harmful if swallowed or in contact with skin Causes severe skin burns and eye damage May cause an allergic skin reaction. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Is Diethylenetriamine (DETA) used outside cosmetics?

Diethylenetriamine (DETA) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does Diethylenetriamine (DETA) have different safety status in cosmetics vs industrial chemicals?

Diethylenetriamine (DETA) is classified GHS Danger (H302, H312, H314, H317, H318, H330, H335, H334) in the chemicals database but is restricted in EU cosmetics.

Compliance Tools

Check Diethylenetriamine (DETA) compliance across multiple jurisdictions:

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Substance Compliance

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MoS Calculator

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Heavy Metal Limits

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Aminoethylethanolamine

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