Warning GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

Diethylene glycol

Also known as: Ethanol, 2,2'-oxybis-, 2-Hydroxyethyl ether, 2,2'-0xydiethanol, 4-01-00-02390, Bis(beta-hydroxyethyl) ether (+10 more)

CAS 111-46-6

Diethylene glycol (CAS 111-46-6) is a chemical substance with GHS signal word Warning; key hazard signal: H302. Key regulatory status: REACH registered, 29 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Diethylene Glycol →

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 20 fields

Name

Diethylene glycol

CAS Number

111-46-6

Molecular Formula

C4H10O3

InChI Key

MTHSVFCYNBDYFN-UHFFFAOYSA-N

Monoisotopic Mass

106.062994

Synonyms

Ethanol, 2,2'-oxybis-2-Hydroxyethyl ether2,2'-0xydiethanol4-01-00-02390Bis(beta-hydroxyethyl) etherBRN 0969209Caswell No. 338AEINECS 203-872-2EPA Pesticide Chemical Code 338200Ethanol, 2,2'-oxydi-Glycol etherGlycol ethyl ether

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Acute Tox. 4 *	H302	GHS07	Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Harmful if swallowed Causes damage to kidneys if swallowed May cause drowsiness and dizziness
Short-term Effects	The substance may cause effects on the kidneys. This may result in kidney impairment. Ingestion could cause effects on the central nervous system and liver. Ingestion could cause death.
Routes of Exposure	The substance can be absorbed into the body by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

EmulsifierSolventDeodorizerFragranceViscosity modifierBinderLubricating agentMonomersNo specific technical functionProcessing aids not otherwise specified

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 29 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
artificial_saliva; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe	Danish Environmental Protection Agency	Danish EPA
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Arts and crafts/Office supplies - home office - pens and markers; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - home office - pens and markers; detected; Europe	Danish Environmental Protection Agency	Danish EPA
CEDI	FDA	United States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
IFRA Transparency	IFRA	IFRA
fracking; water	NY Department of Conservation	CPCat
Arts and crafts/Office supplies - fabric treatment and dye; Arts and crafts/Office supplies - home office - pens and markers; detected	Danish Environmental Protection Agency	Danish EPA
banned; Europe; Personal care	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 40 of 40 studies

Value	Unit	Endpoint	Route	Species	Source
1.6	mg/kg bw/day	-	dermal	-	Regulatory source
10	-	-	-	rat	Regulatory source
50	mg/kg bw/day	-	oral	rat	Regulatory source
200	mg/kg/day	-	-	rat	Regulatory source
=0.5	mg/kg bw/day	ADI (group)	-	Consumers	EFSA
=60	mg/m3	DNEL local	inhalation	Human	ToxValDB GESTIS DNEL
=44	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
61BR964293	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.97	fraction	Fu	-	Human	NTP ICE adme parameters
=1.257e+4	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=1.257e+4	mg/kg bw	LD50	oral	Rat (Female)	NTP ICE acute oral
=1.560e+4	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=1.565e+4	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=1.655e+4	mg/kg bw	LD50	oral	Rat (Male/Female)	NTP ICE acute oral
=1.660e+4	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=2.076e+4	mg/kg bw	LD50	oral	Rat (Male)	NTP ICE acute oral
=2.873e+4	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=3.019e+4	mg/kg bw	LD50	oral	Rat (Male)	NTP ICE acute oral
=6.945e+4	mg/m3	LEL	inhalation	Human	ToxValDB DOE Protective Action Criteria
100	mg/kg bw/day	LOAEL	oral	rat	COSMOS DB
2795	mg/kg bw/day	LOEL	Oral	Mouse	NTP ICE dart
4472	mg/kg bw/day	LOEL	Oral	Rat	NTP ICE dart
1.118e+4	mg/kg bw/day	LOEL	Oral	Mouse	NTP ICE dart
0	unitless	Model Score	-	-	NTP ICE endocrine
=1.6	mg/kg bw/day	NOAEL	dermal	-	SCCS Opinion
=10	-	NOAEL	-	rat	SCCS Opinion
50	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
=50	mg/kg bw/day	NOAEL	oral	rat	SCCS Opinion
=200	mg/kg/day	NOAEL	-	rat	SCCS Opinion
=200	mg/kg bw/day	NOAEL	-	rat	SCCS Opinion
=559	mg/kg bw/day	NOAEL	oral	rat	SCCS Opinion
=612	mg/kg bw/day	NOAEL	oral	rat	SCCS Opinion
=1118	mg/kg bw/day	NOAEL	oral	rat	SCCS Opinion
559	mg/kg bw/day	developmental toxicity	oral	rat	Regulatory source
1118	mg/kg bw/day	developmental toxicity	oral	rat	Regulatory source
50	mg/kg bw/day	genotoxicity	-	rat	Regulatory source
200	mg/kg bw/day	genotoxicity	-	rat	Regulatory source
50	mg/kg bw/day	repeated dose toxicity	-	rat	Regulatory source
50	mg/kg bw/day	reproductive toxicity	oral	rat	Regulatory source
612	mg/kg bw/day	reproductive toxicity	oral	rat	Regulatory source

Showing 40 of 40 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	2,2'-oxydiethanol	203-872-2	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 2 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCP/1181/08	16 December 2008	safe	1.0%	sensitisation potential not excluded
SCCP/1156/08	24 June 2008	not safe	Not safe as cosmetic ingredient	Renal toxicity; metabolised to toxic oxalic acid; not suitable for use in cosmetics

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Subject to Annex III concentration and purity conditions

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed DI(HYDROXYETHYL)ETHER

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Diethylene glycol?

Diethylene glycol (CAS 111-46-6) is classified under EU CLP Annex VI as Acute Tox. 4 * with signal word Warning. Hazard statements: H302. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Diethylene glycol?

Diethylene glycol has 40 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.

What regulatory lists include Diethylene glycol?

Diethylene glycol appears on 14 regulatory/inventory lists including Europe; Personal care; restricted, detected; Europe; Toys and children's products, artificial_saliva; detected; emissions; Europe; Toys and children's products, and 11 more. Source: EPA CPDat.

Is Diethylene glycol used in cosmetics?

Yes, Diethylene glycol is also indexed as a cosmetic ingredient under the name Diethylene Glycol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Diethylene glycol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Diethylene glycol used outside industrial chemicals?

Diethylene glycol also appears in cosmetics, pharmaceutical, cannabis databases.