Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Diethylene Glycol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 50 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| LOAEL | 100 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
DEG should not be intentionally formulated into cosmetic products. It is restricted under EU Annex III, prohibited in China and Canada, and banned in oral cosmetics above 0.25% in Australia. Its primary hazard is as a contaminant in glycerin and glycol-based raw materials, associated with mass poisoning incidents.
Regulatory Flags
Frequently Asked Questions
Is Diethylene Glycol safe in cosmetics?
DEG should not be intentionally formulated into cosmetic products. It is restricted under EU Annex III, prohibited in China and Canada, and banned in oral cosmetics above 0.25% in Australia. Its primary hazard is as a contaminant in glycerin and glycol-based raw materials, associated with mass poisoning incidents. The EU classifies Diethylene Glycol as "restricted". Safety rating: POOR. 2 toxicological study endpoint(s) are available in our database.
Is Diethylene Glycol allowed in the EU?
Diethylene Glycol EU regulatory status: restricted. Maximum allowed concentration: Subject to Annex III concentration and purity conditions. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethylene Glycol do in cosmetics?
Diethylene Glycol functions as: Solvent, Viscosity Controlling. It is classified as a cosmetic ingredient in our database. CAS number: 111-46-6.
What is the Margin of Safety for Diethylene Glycol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diethylene Glycol?
The NOAEL (No Observed Adverse Effect Level) for Diethylene Glycol is 50 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Is Diethylene Glycol classified as hazardous under GHS?
Diethylene Glycol carries a GHS signal word of "DANGER". Hazard statements: Harmful if swallowed Causes damage to kidneys if swallowed May cause drowsiness and dizziness. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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Related Ingredients
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