What is the GHS hazard classification for 2,2'-Thiobisethanol?
2,2'-Thiobisethanol (CAS 111-48-8) is classified under EU CLP Annex VI as Eye Irrit. 2 with signal word Warning. Hazard statements: H319. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
2,2'-Thiobisethanol
Also known as: Bis(beta-hydroxyethyl) sulfide, Bis(beta-hydroxyethyl)sulfide, BRN 1236325, EINECS 203-874-3, Glyecine A (+13 more)
CAS 111-48-8
2,2'-Thiobisethanol (CAS 111-48-8) is a chemical substance with GHS signal word Warning; key hazard signal: H319. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
24 fields
Name
2,2'-Thiobisethanol
CAS Number
111-48-8
DTXSID
DTXSID6026878
Molecular Formula
C4H10O2S
InChI Key
YODZTKMDCQEPHD-UHFFFAOYSA-N
Monoisotopic Mass
122.040151
Synonyms
Bis(beta-hydroxyethyl) sulfideBis(beta-hydroxyethyl)sulfideBRN 1236325EINECS 203-874-3Glyecine ASulfide, bis(2-hydroxyethyl)ThiodiglycolumUNII-9BW5T43J042,2'-Sulfobisethanol2-[(2-hydroxyethyl)sulfanyl]ethan-1-olBis(2-hydroxyethyl) sulphideBis(2-hydroxyethyl)sulfide
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Eye Irrit. 2 | H319 | GHS07 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is mildly irritating to the eyes and respiratory tract. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Antioxidant
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =215 | mg/kg bw/day | BMDL | oral | Rat | ToxValDB_PPRTV_(CPHEA) |
| =17.6 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 9BW5T43J04 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9BW5T43J04 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9BW5T43J04 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9BW5T43J04 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =6610 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HESS |
| =0.07 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
| =0.7 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Thiodiglycol | 203-874-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
THIODIGLYCOL
ChEMBL Phase
2
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
What is the NOAEL for 2,2'-Thiobisethanol?
2,2'-Thiobisethanol has 10 NOAEL studies in the database. The lowest reported value is 17.6 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Is 2,2'-Thiobisethanol used in cosmetics?
Yes, 2,2'-Thiobisethanol is also indexed as a cosmetic ingredient under the name Thiodiglycol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,2'-Thiobisethanol come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 2,2'-Thiobisethanol used outside industrial chemicals?
2,2'-Thiobisethanol also appears in cosmetics, pharmaceutical databases.