Thiodiglycol
INCI: THIODIGLYCOL (2,2′-THIODIETHANOL)
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Thiodiglycol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 500 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 5000 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
CWC Schedule 2 precursor (mustard gas precursor) – procurement, storage, and reporting obligations; verify supply chain compliance
Frequently Asked Questions
Is Thiodiglycol safe in cosmetics?
CWC Schedule 2 precursor (mustard gas precursor) – procurement, storage, and reporting obligations; verify supply chain compliance The EU classifies Thiodiglycol as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is Thiodiglycol allowed in the EU?
Thiodiglycol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Thiodiglycol do in cosmetics?
Thiodiglycol functions as: Antioxidant, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 111-48-8.
What is the Margin of Safety for Thiodiglycol?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Thiodiglycol?
The NOAEL (No Observed Adverse Effect Level) for Thiodiglycol is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
Check Thiodiglycol compliance across multiple jurisdictions:
Related Ingredients
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