Is Thiodiglycol safe in cosmetics?
Thiodiglycol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: restricted.
Thiodiglycol
Also known as: Bis(beta-hydroxyethyl) sulfide, Bis(beta-hydroxyethyl)sulfide, BRN 1236325, EINECS 203-874-3, Glyecine A (+13 more)
INCI: THIODIGLYCOL (2,2′-THIODIETHANOL)
Thiodiglycol (CAS 111-48-8) is a cosmetic cosmetic ingredient functioning as Antioxidant, Solvent. NOAEL 500 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 111-48-8 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, Solvent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-(2-hydroxyethylsulfanyl)ethanol
InChIKey
YODZTKMDCQEPHD-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Not specifically restricted for cosmetics; CWC Schedule 2 substance requires DEA reporting for procurement
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Thiodiglycol.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is mildly irritating to the eyes and respiratory tract.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Thiodiglycol across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Eye Irrit. 2
Hazard Statements
- H319 Causes serious eye irritation
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
1601
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
A skin and eye irritant. | The substance is mildly irritating to the eyes and the respiratory tract.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Expert Verdict
Expert safety assessment and concern-level summary for Thiodiglycol.
Known Synonyms
Bis(beta-hydroxyethyl) sulfide
Bis(beta-hydroxyethyl)sulfide
BRN 1236325
EINECS 203-874-3
Glyecine A
Sulfide, bis(2-hydroxyethyl)
Thiodiglycolum
UNII-9BW5T43J04
2,2'-Sulfobisethanol
2-[(2-hydroxyethyl)sulfanyl]ethan-1-ol
Bis(2-hydroxyethyl) sulphide
Bis(2-hydroxyethyl)sulfide
Bis(hydroxyethyl)sulfide
Dihydroxyethyl sulfide
Thiodiethanol
Tiodiglicolo
beta,beta'-Dihydroxydiethyl sulfide
beta,beta'-dihydroxyethyl sulfide
Chemical Function
Antioxidant
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
THIODIGLYCOL
ChEMBL ID
CHEMBL444480
Max Phase
2
Frequently Asked Questions
Is Thiodiglycol allowed in the EU?
Thiodiglycol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Thiodiglycol do in cosmetics?
Thiodiglycol functions as: Antioxidant, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 111-48-8.
Is Thiodiglycol used outside cosmetics?
Thiodiglycol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Thiodiglycol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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