Also known as: 2-(2-Methoxyethoxy)ethanol, Ethanol, 2-(2-methoxyethoxy)-, Diethylene glycol methyl ether, Ethanol, 2-(2-methoxyethoxy)- 2-(2-Methoxyethoxy)ethan-1-ol, 4-01-00-02392 (+13 more)
CAS 111-77-3
Diethylene glycol monomethyl ether (CAS 111-77-3) is a chemical substance with GHS signal word Danger; key hazard signal: H360D. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Diethylene glycol monomethyl ether is classified GHS Danger (H360D) in the chemicals database but is restricted in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Repr. 1B | H360D | GHS08 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. Animal tests show that this substance possibly causes toxicity to human reproduction or development. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| consumer_product | P&G | Proctor & Gamble |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| IFRA Transparency | IFRA | IFRA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =12 | mg/kg bw/day | BMDL (05 HED) | oral | Rat | ToxValDB_PPRTV_(CPHEA) |
| =50.1 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 465DDJ8G8K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 465DDJ8G8K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 465DDJ8G8K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 465DDJ8G8K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 12960 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =5500 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =6310 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =7128 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =9210 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =12410 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =67813.9 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| 69 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =50 | mg/kg bw/day | NOEL | dermal | Rabbit | ToxValDB_EU_SCOEL |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| =0.04 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
Showing 19 of 19 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-(2-methoxyethoxy)ethanol | 203-906-6 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Diethylene glycol monomethyl ether (CAS 111-77-3) is classified under EU CLP Annex VI as Repr. 1B with signal word Danger. Hazard statements: H360D. Source: EU CLP Annex VI (ECHA).
Diethylene glycol monomethyl ether has 19 NOAEL studies in the database. The lowest reported value is 12 mg/kg bw/day via oral in Rat. Source: ToxValDB_PPRTV_(CPHEA).
Diethylene glycol monomethyl ether appears on 5 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, consumer_product, CEDI, and 2 more. Source: EPA CPDat.
Yes, Diethylene glycol monomethyl ether is also indexed as a cosmetic ingredient under the name Methoxydiglycol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Diethylene glycol monomethyl ether is classified GHS Danger (H360D) in the chemicals database but is restricted in EU cosmetics.
Diethylene glycol monomethyl ether also appears in cosmetics, pharmaceutical databases.