Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Methoxydiglycol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 69 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Acts as a penetration enhancer, potentially facilitating transport of harmful substances through the skin; production impurities may pose health risks; teratogenic agent classification in toxicological databases. Diethylene glycol monomethyl ether (DEGMME); colorless, odorless, hygroscopic liquid; excellent solvency for organic compounds; also known as Methyl Carbitol
Regulatory Flags
Frequently Asked Questions
Is Methoxydiglycol safe in cosmetics?
Acts as a penetration enhancer, potentially facilitating transport of harmful substances through the skin; production impurities may pose health risks; teratogenic agent classification in toxicological databases. Diethylene glycol monomethyl ether (DEGMME); colorless, odorless, hygroscopic liquid; excellent solvency for organic compounds; also known as Methyl Carbitol The EU classifies Methoxydiglycol as "restricted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.
Is Methoxydiglycol allowed in the EU?
Methoxydiglycol EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methoxydiglycol do in cosmetics?
Methoxydiglycol functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 111-77-3.
What is the Margin of Safety for Methoxydiglycol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Methoxydiglycol?
The NOAEL (No Observed Adverse Effect Level) for Methoxydiglycol is 69 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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