What is the NOAEL for 2-(2-Ethoxyethoxy)ethanol?
2-(2-Ethoxyethoxy)ethanol has 51 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-(2-Ethoxyethoxy)ethanol
Also known as: Diethylene glycol monoethyl ether, BRN 1736441, Carbitol cellosolve, Carbitol solvent, Diethyleneglycol monoethyl ether (+10 more)
CAS 111-90-0
2-(2-Ethoxyethoxy)ethanol (CAS 111-90-0) is a chemical substance. Key regulatory status: REACH registered, 26 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
2-(2-Ethoxyethoxy)ethanol is classified GHS Danger (H227, H320, H372) in the chemicals database but is restricted in EU cosmetics at max Leave-on non-spray: 2.6%; rinse-off: 10%; oxidative hair dye: 7%; non-oxidative hair dye: 5%; spray products: 2.6%. Ethylene glycol impurity must be <=0.1%..
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
51
SOURCE
Chemical inventory jurisdictions
Regulatory lists
26
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
2-(2-Ethoxyethoxy)ethanol
CAS Number
111-90-0
Molecular Formula
C6H14O3
InChI Key
XXJWXESWEXIICW-UHFFFAOYSA-N
Monoisotopic Mass
134.094294
Synonyms
Diethylene glycol monoethyl etherBRN 1736441Carbitol cellosolveCarbitol solventDiethyleneglycol monoethyl etherEINECS 203-919-7Ethyl diethylene glycolLosungsmittel APVMonoethyl ether of diethylene glycol3,6-Dioxa-1-oktanolAethyldiaethylenglycolKarbitol
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is mildly irritating to the eyes. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
SolventHumectantFragranceViscosity modifierProcessing aids not otherwise specifiedSolubility enhancerEmulsifierAdhesion/cohesion promoter
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
26 records
| List | Keyword | Source |
|---|---|---|
| artificial_saliva; detected; emissions; Europe; Furniture and Furnishings | Danish Environmental Protection Agency | Danish EPA |
| Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - home office - pens and markers; detected | Danish Environmental Protection Agency | Danish EPA |
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Specialty occupational products | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care; restricted | European Commission | CosIng |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 51 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1 | % | - | oral | rat | Regulatory source |
| 1 | % | - | - | rat | Regulatory source |
| 5 | % | - | oral | rat | Regulatory source |
| 5 | - | - | inhalation | rat | Regulatory source |
| 5.4 | % | - | oral | mouse | Regulatory source |
| 10 | % | - | - | human | Regulatory source |
| 29.5 | % | - | - | rat | Regulatory source |
| 102 | ppm | - | - | rat | Regulatory source |
| 167 | mg/kg bw/d | - | dermal | rabbit | Regulatory source |
| 167 | mg/kg bw/day | - | dermal | rabbit | Regulatory source |
| =167 | mg/kg bw/day | - | oral | rat | Regulatory source |
| =167 | mg/kg bw/day | - | - | pig | Regulatory source |
| 180 | mg/kg bw/d | - | oral | rat | Regulatory source |
| =180 | mg/kg bw/day | - | oral | rat | Regulatory source |
| 180 | mg/kg | - | - | rat | Regulatory source |
| =180 | mg/kg bw/day | - | - | rat | Regulatory source |
| 200 | mg/kg bw/day | - | oral | rat | Regulatory source |
| 200 | mg/kg bw/day | - | oral | dog | Regulatory source |
| =200 | mg/kg bw/day | - | - | rat | Regulatory source |
| 250 | mg/kg bw/day | - | oral | rat | Regulatory source |
| =400 | mg/kg bw/day | - | - | dog | Regulatory source |
| 500 | mg/kg bw/d | - | oral | rat | Regulatory source |
| 500 | mg/kg bw/day | - | oral | rat | Regulatory source |
| 800 | mg/kg bw/day | - | oral | rat | Regulatory source |
| 850 | mg/kg bw/d | - | oral | mouse | Regulatory source |
| 850 | mg/kg bw/day | - | oral | mouse | Regulatory source |
| 1000 | mg/kg bw/d | - | oral | rat | Regulatory source |
| 1000 | mg/kg bw | - | oral | - | Regulatory source |
| 1000 | mg/kg bw/day | - | oral | rat | Regulatory source |
| 1000 | mg/kg | - | - | pig | Regulatory source |
| 1000 | mg/kg bw/day | - | oral | mouse | Regulatory source |
| 1340 | mg/kg bw | - | oral | rat | Regulatory source |
| =1340 | mg/kg bw/day | - | oral | rat | Regulatory source |
| =1340 | mg/kg bw/day | - | - | rat | Regulatory source |
| 1340 | mg/kg bw | - | - | rat | Regulatory source |
| 1500 | mg/kg bw/d | - | oral | rat | Regulatory source |
| 1500 | mg/kg bw | - | oral | - | Regulatory source |
| 1500 | mg/kg | - | - | dog | Regulatory source |
| 5360 | mg/kg | - | - | rat | Regulatory source |
| =1 | mg/m3 | BMCL (10 HEC) | inhalation | Rat | ToxValDB PPRTV (CPHEA) |
| =30 | mg/m3 | DNEL local | inhalation | Human | ToxValDB GESTIS DNEL |
| A1A1I8X02B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 1.296e+4 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| >5.24 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| <5 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1920 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =5540 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =5600 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
Showing 50 of 51 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-(2-ethoxyethoxy)ethanol | 203-919-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
SCCS Opinion
7 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1507/13 | 18 June 2013 | safe with restrictions | Various (solvent in cosmetics) | Solvent; limited systemic toxicity at cosmetic use levels |
| SCCS/1501/12 | 18 June 2013 | Safe — safe for use as solvent/co-solvent in cosmetics (refer to SCCS/1507/13 for revised full opinion) | See SCCS/1507/13 (revised opinion) | Nephrotoxicity at high doses; systemic exposure via dermal route evaluated |
| SCCS/1406/11 | 21 September 2010 | safe with restrictions | Various (solvent) | Solvent; systemic toxicity data reviewed; acceptable safety profile at cosmetic concentrations |
| SCCP/1189/08 | 16 December 2008 | safe with restrictions | Various (solvent) | Previous assessment confirmed; low systemic toxicity |
| SCCP/0992/06 | 19 December 2006 | safe with restrictions | Various | Solvent; low systemic toxicity |
| SCCP/1044/06 | 2006-12-19 | Based on the information provided, the SCCP is of the opinion that the use of diethylene glycol monoethyl ether (DEGEE) in all cosmetic products, except products for oral hygiene and eye products at a concentrations up to 1.5% does not pose a risk to the health of the consumer, provided that the level of ethylene glycol in DEGEE used is < 0.2%. | 1.5% | Requires ethylene glycol impurity level < 0.2% in DEGEE; opinion limited to dermal application, excludes aerosol/spray exposure. |
| SCCS/1316/10 | 2010-09-21 | Based on the new information submitted, SCCS is of the opinion that: 1. the use of DEGEE as a solvent in cosmetic products in a concentration up to 10% in rinse-off products does not pose a risk to the health of the consumer. 2. the use of DEGEE as a solvent in cosmetic products in a concentration up to 5.5% in leave-on products does pose a risk to the health of the consumer. 3. an additional use of DEGEE as solvent in an on-head concentration up to 7.0% in oxidative hair dye formulations and up to 5.0% in non-oxidative hair dye formulations does not pose a risk to the health of the consumer. 4. the additional use of DEGEE at concentrations up to 1.5% in all cosmetic products does not pose a risk to the health of the consumer. | Up to 10% in rinse-off (safe); up to 1.5% in all cosmetic products (safe); up to 7.0% on-head in oxidative and up to 5.0% on-head in non-oxidative hair dyes (safe); 5.5% in leave-on products NOT safe | Ethylene glycol level in DEGEE must be < 0.2%. Opinion relates to dermal application only; does not cover aerosol/spray exposure or aggregate non-cosmetic exposure. Use at 5.5% in leave-on products specifically does pose a risk. |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
Leave-on non-spray: 2.6%; rinse-off: 10%; oxidative hair dye: 7%; non-oxidative hair dye: 5%; spray products: 2.6%. Ethylene glycol impurity must be <=0.1%.
Category
Solvents
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
DIETHYLENE GLYCOL MONOETHYL ETHER
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 2-(2-Ethoxyethoxy)ethanol?
2-(2-Ethoxyethoxy)ethanol appears on 16 regulatory/inventory lists including artificial_saliva; detected; emissions; Europe; Furniture and Furnishings, Europe; Vehicle - car interior, detected; Europe; Vehicle - car interior, and 13 more. Source: EPA CPDat.
Is 2-(2-Ethoxyethoxy)ethanol used in cosmetics?
Yes, 2-(2-Ethoxyethoxy)ethanol is also indexed as a cosmetic ingredient under the name Ethoxydiglycol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-(2-Ethoxyethoxy)ethanol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-(2-Ethoxyethoxy)ethanol have different safety status in cosmetics vs industrial chemicals?
2-(2-Ethoxyethoxy)ethanol is classified GHS Danger (H227, H320, H372) in the chemicals database but is restricted in EU cosmetics at max Leave-on non-spray: 2.6%; rinse-off: 10%; oxidative hair dye: 7%; non-oxidative hair dye: 5%; spray products: 2.6%. Ethylene glycol impurity must be <=0.1%..
Is 2-(2-Ethoxyethoxy)ethanol used outside industrial chemicals?
2-(2-Ethoxyethoxy)ethanol also appears in cosmetics, pharmaceutical databases.