Good Cosmetic Ingredient NOAEL Data GHS Classified

Ethoxydiglycol

INCI: ETHOXYDIGLYCOL

CAS Number

111-90-0

Function

Solvent, Humectant, Penetration Enhancer

Safety Rating

GOOD

Regulatory Status

🇪🇺 EU Status restricted

EU Max Conc. Leave-on non-spray: 2.6%; rinse-off: 10%; oxidative hair dye: 7%; non-oxidative hair dye: 5%; spray products: 2.6%. Ethylene glycol impurity must be <=0.1%.

🇺🇸 US Status permitted

US Notes CIR (1985, reaffirmed 2004) concluded safe at 0.0004-80% depending on product type; no FDA concentration restrictions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

adequate

Dermal Absorption

high

Sensitization

low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Ethoxydiglycol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOEL	100 mg/kg bw/day	dermal	code:3484	dermal	REACH
NOAEL	1000 mg/kg bw/day	oral	dog	oral	REACH
NOAEL	ca.0.5 other	oral	rat	oral	REACH
NOEL	ca.1 other	oral	rat	oral	REACH
NOAEL	1340 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	ca.3 other	oral	mouse	oral	REACH
NOAEL	ca.167 mg/kg bw/day	oral	pig	oral	REACH
NOAEL	335 mg/kg bw/day	oral	mouse	oral	REACH
NOAEL	1000 mg/kg bw/day	oral	mouse	oral	REACH
NOAEL	2.16 other	oral	rat	oral	REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects

The substance is mildly irritating to the eyes.

Long-term Exposure Effects

The substance defats the skin, which may cause dryness or cracking.

Expert Verdict

Restricted in EU under Annex III entry 297; safe within permitted limits; verify ethylene glycol impurity <=0.1% on CoA; not for use in eye or oral hygiene products.

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Concern Level: Low

Regulatory Flags

annex-iii-restricted penetration-enhancer high-dermal-absorption impurity-control-required not-for-eye-products not-for-oral-hygiene ifra_fragrance eu_cosing_listed jecfa_concern

Frequently Asked Questions

Is Ethoxydiglycol safe in cosmetics?

Restricted in EU under Annex III entry 297; safe within permitted limits; verify ethylene glycol impurity <=0.1% on CoA; not for use in eye or oral hygiene products. The EU classifies Ethoxydiglycol as "restricted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is Ethoxydiglycol allowed in the EU?

Ethoxydiglycol EU regulatory status: restricted. Maximum allowed concentration: Leave-on non-spray: 2.6%; rinse-off: 10%; oxidative hair dye: 7%; non-oxidative hair dye: 5%; spray products: 2.6%. Ethylene glycol impurity must be <=0.1%.. This is based on EU Regulation 1223/2009 and its amendments.

What does Ethoxydiglycol do in cosmetics?

Ethoxydiglycol functions as: Solvent, Humectant, Penetration Enhancer. It is classified as a cosmetic ingredient in our database. CAS number: 111-90-0.

What is the Margin of Safety for Ethoxydiglycol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Ethoxydiglycol?

The NOAEL (No Observed Adverse Effect Level) for Ethoxydiglycol is 100 mg/kg bw/day based on a dermal study via dermal route in code:3484. A total of 10 study endpoints are available. Source: REACH.

Compliance Tools

Check Ethoxydiglycol compliance across multiple jurisdictions:

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82 Allergen Checker

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Substance Compliance

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MoS Calculator

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Heavy Metal Limits

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