What is the NOAEL for Dimethyl glutarate?
Dimethyl glutarate has 15 NOAEL studies in the database. The lowest reported value is 8.3 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dimethyl glutarate
Also known as: Pentanedioic acid, dimethyl ester, DBE 5, NSC 58578, EINECS 214-277-2, UNII-1I9VFA346P (+1 more)
CAS 1119-40-0
Dimethyl glutarate (CAS 1119-40-0) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
15
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
Dimethyl glutarate
CAS Number
1119-40-0
DTXSID
DTXSID3025122
Molecular Formula
C7H12O4
InChI Key
XTDYIOOONNVFMA-UHFFFAOYSA-N
Monoisotopic Mass
160.073559
Synonyms
Pentanedioic acid, dimethyl esterDBE 5NSC 58578EINECS 214-277-2UNII-1I9VFA346P1,5-Dimethyl pentanedioate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
SolventSoftener and conditionerAnti-static agentBinderPlasticizerSurface modifierAdhesion/cohesion promoterFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| artificial_sweat; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| artificial_saliva; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 46.3 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =8.3 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 1I9VFA346P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1I9VFA346P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1I9VFA346P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1I9VFA346P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.6989 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| =20 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =390 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HESS |
| >=1000 | mg/kg bw/day | NOAEL | inhalation | Rabbit | ToxValDB_ECHA_IUCLID |
| =10 | mg/m3 | NOEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =50 | mg/m3 | NOEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
Showing 15 of 15 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dimethyl glutarate | 214-277-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1609626
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include Dimethyl glutarate?
Dimethyl glutarate appears on 8 regulatory/inventory lists including CEDI, Indirect additives food contact (10/2018), SCIL (9/2019), and 5 more. Source: EPA CPDat.
Is Dimethyl glutarate used in cosmetics?
Yes, Dimethyl glutarate is also indexed as a cosmetic ingredient under the name Dimethyl Glutarate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dimethyl glutarate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Dimethyl glutarate used outside industrial chemicals?
Dimethyl glutarate also appears in cosmetics, pharmaceutical databases.