What is the NOAEL for Triethylene glycol?
Triethylene glycol has 26 NOAEL studies in the database. The lowest reported value is 70.8 mg/kg bw/day via oral in Mouse. Source: ToxValDB PPRTV (CPHEA).
NOAEL Data
REACH Registered
Cosmetic Ingredient
Triethylene glycol
Also known as: Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, 4-01-00-02400, Bis(2-hydroxyethoxyethane), BRN 0969357, Caswell No. 888 (+14 more)
CAS 112-27-6
Triethylene glycol (CAS 112-27-6) is a chemical substance. Key regulatory status: REACH registered, 50 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
Triethylene glycol is classified GHS Danger (H302, H312, H314, H412) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
26
SOURCE
Chemical inventory jurisdictions
Regulatory lists
50
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
24 fields
Name
Triethylene glycol
CAS Number
112-27-6
Molecular Formula
C6H14O4
InChI Key
ZIBGPFATKBEMQZ-UHFFFAOYSA-N
Monoisotopic Mass
150.089209
Synonyms
Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-4-01-00-02400Bis(2-hydroxyethoxyethane)BRN 0969357Caswell No. 888EINECS 203-953-2EPA Pesticide Chemical Code 083501Ethanol, 2,2'-(ethylenedioxy)di-Ethylene glycol dihydroxydiethyl etherEthylene glycol-bis-(2-hydroxyethyl ether)2,2'-EthylenedioxyethanolTriethyleneglycol
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceDeodorizerViscosity modifierSolventPigmentMonomersSolubility enhancerPlasticizerWetting agent (non-aqueous)
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
50 records
| List | Keyword | Source |
|---|---|---|
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| Arts and crafts/Office supplies - home office - pens and markers; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 26 of 26 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =70.8 | mg/kg bw/day | BMDL (05 HED) | oral | Mouse | ToxValDB PPRTV (CPHEA) |
| 3P5SU53360 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 1.350e+4 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| =1.700e+4 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1.890e+4 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =2.206e+4 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =3.167e+4 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| >2250 | mg/kg bw/day | LEL | injection | Rabbit | ToxValDB ToxRefDB |
| =1.127e+4 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB ToxRefDB |
| =1.127e+4 | mg/kg bw/day | LEL | oral | mouse (cd1; CD) | EPA ToxRefDB v3 |
| =5.528e+4 | mg/m3 | LEL | inhalation | Human | ToxValDB DOE Protective Action Criteria |
| 1.127e+4 | mg/kg bw/day | LOEL | Oral | Mouse | NTP ICE dart |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| =4500 | mg/kg bw/day | NEL | oral | Mouse | ToxValDB ToxRefDB |
| =4500 | mg/kg bw/day | NEL | oral | mouse (cd1; CD) | EPA ToxRefDB v3 |
| =1920 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB HESS |
| =1.127e+4 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB ECOTOX |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
| =2 | mg/kg bw/day | RfD | oral | Human | ToxValDB Pennsylvania DEP ToxValues |
| 94.95 | % | Viability | Dermal | - | NTP ICE skin irritation |
| 94.99 | % | Viability | Dermal | - | NTP ICE skin irritation |
| 95.29 | % | Viability | Dermal | - | NTP ICE skin irritation |
| 97.97 | % | Viability | Dermal | - | NTP ICE skin irritation |
| 100.6 | % | Viability | Dermal | - | NTP ICE skin irritation |
| 101.5 | % | Viability | Dermal | - | NTP ICE skin irritation |
Showing 26 of 26 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
TRIETHYLENE GLYCOL
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include Triethylene glycol?
Triethylene glycol appears on 22 regulatory/inventory lists including Europe; plastic_additive, active_ingredient; Europe; Pesticides, inert_ingredient; non_food_use; Pesticides, and 19 more. Source: EPA CPDat.
Is Triethylene glycol used in cosmetics?
Yes, Triethylene glycol is also indexed as a cosmetic ingredient under the name Triethylene Glycol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Triethylene glycol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Triethylene glycol have different safety status in cosmetics vs industrial chemicals?
Triethylene glycol is classified GHS Danger (H302, H312, H314, H412) in the chemicals database but is allowed in EU cosmetics.
Is Triethylene glycol used outside industrial chemicals?
Triethylene glycol also appears in cosmetics, pharmaceutical databases.