What is the GHS hazard classification for 2-(2-Butoxyethoxy)ethanol?
2-(2-Butoxyethoxy)ethanol (CAS 112-34-5) is classified under EU CLP Annex VI as Eye Irrit. 2 with signal word Warning. Hazard statements: H319. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-(2-Butoxyethoxy)ethanol
Also known as: Diethylene glycol monobutyl ether, BRN 1739225, Butoxy diethylene glycol, Caswell No. 121B, Caswell No. 125H (+6 more)
CAS 112-34-5
2-(2-Butoxyethoxy)ethanol (CAS 112-34-5) is a chemical substance with GHS signal word Warning; key hazard signal: H319. Key regulatory status: REACH registered, 23 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH, ILO ICSC, OSHA.
SOURCE
NOAEL studies
NOAEL studies
50
SOURCE
Chemical inventory jurisdictions
Regulatory lists
23
SOURCE
EU CLP Annex VI
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
2-(2-Butoxyethoxy)ethanol
CAS Number
112-34-5
Molecular Formula
C8H18O3
InChI Key
OAYXUHPQHDHDDZ-UHFFFAOYSA-N
Monoisotopic Mass
162.125594
Synonyms
Diethylene glycol monobutyl etherBRN 1739225Butoxy diethylene glycolCaswell No. 121BCaswell No. 125HDiethylene gylcol monobutyl etherEINECS 203-961-6EPA Pesticide Chemical Code 011502Glycol ether DBJeffersol DBUNII-9TB90IYC0E
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Eye Irrit. 2 | H319 | GHS07 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
1 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| ACGIH | TWA | 10 ppm (inhalable fraction and vapor) [2012] | 10 | - | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
SolventDeodorizerViscosity modifierFragranceCleaning agentDiluentProcessing aids not otherwise specifiedCoalescing agentNo specific technical functionStabilizing agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
23 records
| List | Keyword | Source |
|---|---|---|
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - home office - pens and markers; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - fabric treatment and dye; detected | Danish Environmental Protection Agency | Danish EPA |
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Europe; Specialty occupational products | Danish Environmental Protection Agency | Danish EPA |
| Europe; Specialty occupational products | Danish Environmental Protection Agency | Danish EPA |
| Europe; Specialty occupational products | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Specialty occupational products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other indirect contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - oven - oven cleaner; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - oven - oven cleaner; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - oven - oven cleaner; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Cleaning products and household care - oven - oven cleaner; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - oven - oven cleaner; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| IFRA Transparency | IFRA | IFRA |
| Europe; Personal care; restricted | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 50 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 250 | mg/kg bw/day | - | dermal | rat | Regulatory source |
| 250 | mg/kg bw/d | - | oral | rat | Regulatory source |
| 580 | mg/kg bw/day | - | dermal | rat | Regulatory source |
| 2000 | mg/kg | - | - | - | Regulatory source |
| =0.32 | mg/m3 | BMCL (10 HEC) | inhalation | Rat | ToxValDB PPRTV (CPHEA) |
| =81 | mg/kg bw/day | BMDL | oral | Rat | ToxValDB PPRTV (CPHEA) |
| =67.5 | mg/m3 | DNEL local | inhalation | Human | ToxValDB GESTIS DNEL |
| 9TB90IYC0E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =4500 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =5080 | mg/kg bw | LD50 | oral | Rat (Female) | NTP ICE acute oral |
| =5660 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =6050 | mg/kg bw | LD50 | oral | Rat (Female) | NTP ICE acute oral |
| =6530 | mg/kg bw | LD50 | oral | Rat (Male) | NTP ICE acute oral |
| =6560 | mg/kg bw | LD50 | oral | Rat (Male) | NTP ICE acute oral |
| =6600 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =7291 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =7292 | mg/kg bw | LD50 | oral | Rat (Male) | NTP ICE acute oral |
| =7300 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =9623 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =5.640e+4 | mg/m3 | LEL | inhalation | Human | ToxValDB DOE Protective Action Criteria |
| =250 | mg/kg bw/day | LOAEC | oral | Rat | ECHA |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| =500 | mg/kg bw/day | NOAEC | oral | Rat | ECHA |
| =2.6 | mg/kg | NOAEL | oral | rat | SCCS Opinion |
| =50 | % | NOAEL | oral | rat | SCCS Opinion |
| =51 | mg/kg bw/day | NOAEL | oral | rat | SCCS Opinion |
| =250 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB HESS |
| =250 | mg/kg bw/day | NOAEL | dermal | rat | SCCS Opinion |
| =250 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =250 | mg/kg | NOAEL | oral | rat | SCCS Opinion |
| =500 | mg/kg bw/day | NOAEL | oral | Mouse | ECHA |
| =500 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =580 | mg/kg bw/day | NOAEL | dermal | rat | SCCS Opinion |
| =1000 | mg/kg bw/day | NOAEL | oral | rat | SCCS Opinion |
| =2000 | mg/kg | NOAEL | - | - | SCCS Opinion |
| =94 | mg/m3 | NOEL | inhalation | Rat | ToxValDB EU SCOEL |
| =2050 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB ECOTOX |
| =0.0001 | mg/m3 | RfC (provisional) | inhalation | Human | ToxValDB PPRTV (CPHEA) |
| =0.001 | mg/m3 | RfC (provisional) | inhalation | Human | ToxValDB PPRTV (CPHEA) |
| =0.03 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB PPRTV (CPHEA) |
| =0.3 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB PPRTV (CPHEA) |
| =2.6 | mg/kg | dermal absorption | oral | rat | Regulatory source |
| 50 | % | dermal absorption | oral | rat | Regulatory source |
| =250 | mg/kg | dermal absorption | oral | rat | Regulatory source |
| 250 | mg/kg bw/d | genotoxicity | oral | rat | Regulatory source |
| 51 | mg/kg bw/day | repeated dose toxicity | oral | rat | Regulatory source |
| 500 | mg/kg bw/d | reproductive toxicity | oral | rat | Regulatory source |
| 1000 | mg/kg bw/day | reproductive toxicity | oral | rat | Regulatory source |
| 1000 | mg/kg bw/d | reproductive toxicity | oral | rat | Regulatory source |
Showing 50 of 50 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-(2-butoxyethoxy)ethanol | 203-961-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
SCCS Opinion
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/1043/06 | 2006-12-19 | Based on the information provided, the SCCP is of the opinion that the use of diethylene glycol monobutyl ether (DEGBE) as a solvent in hair dye formulations at a concentration up to 9.0% does not pose a risk to the health of the consumer. The opinion relates to the direct application to the hair/scalp. It does not include any other cosmetic exposure, such as exposure from other types of cosmetics or possible aerosol/spray products. | 9.0% | Opinion limited to hair/scalp application; does not cover other cosmetic exposure or aerosol/spray products. |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL1904721
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What is the NOAEL for 2-(2-Butoxyethoxy)ethanol?
2-(2-Butoxyethoxy)ethanol has 50 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.
What regulatory lists include 2-(2-Butoxyethoxy)ethanol?
2-(2-Butoxyethoxy)ethanol appears on 17 regulatory/inventory lists including Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe, detected; Other direct contact consumer goods, Arts and crafts/Office supplies - home office - pens and markers; detected; Europe, and 14 more. Source: EPA CPDat.
What are the occupational exposure limits for 2-(2-Butoxyethoxy)ethanol?
Occupational exposure limits for 2-(2-Butoxyethoxy)ethanol are set by ACGIH. 1 limit value from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is 2-(2-Butoxyethoxy)ethanol used in cosmetics?
Yes, 2-(2-Butoxyethoxy)ethanol is also indexed as a cosmetic ingredient under the name Butoxydiglycol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-(2-Butoxyethoxy)ethanol come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 2-(2-Butoxyethoxy)ethanol used outside industrial chemicals?
2-(2-Butoxyethoxy)ethanol also appears in cosmetics, pharmaceutical databases.