Is Butoxydiglycol safe in cosmetics?
Butoxydiglycol has a safety rating of "MODERATE" in our database. EU status: restricted. US status: restricted. 10 toxicological study endpoint(s) are available in our database.
Butoxydiglycol
Also known as: Diethylene glycol monobutyl ether, BRN 1739225, Butoxy diethylene glycol, Caswell No. 121B, Caswell No. 125H (+6 more)
INCI: BUTOXYDIGLYCOL
Butoxydiglycol (CAS 112-34-5) is a cosmetic cosmetic ingredient functioning as Solvent. NOAEL 250 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 112-34-5 →
Auto-generated CPSR Part A draft with source citations
Function
Solvent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-(2-butoxyethoxy)ethanol
InChIKey
OAYXUHPQHDHDDZ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
restricted
US Notes
Conditional – must comply with Annex III entry 187 concentration limits
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Butoxydiglycol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Butoxydiglycol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =2.6 mg/kg | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =2.6 mg/kg | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =2.6 mg/kg | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =2.6 mg/kg | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =51 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS Opinion |
| NOAEL | =51 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS Opinion |
| NOAEL | =51 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS Opinion |
| NOAEL | =51 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS Opinion |
| NOAEL | =500 mg/kg bw/d | oral | rat | reproductive toxicity | SCCS Opinion |
| NOAEL | =500 mg/kg bw/d | oral | rat | reproductive toxicity | SCCS Opinion |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Butoxydiglycol across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LEL | =56398.9 mg/m3 | Human | inhalation | - | DOE Protective Action Criteria |
| NOAEL | =250 mg/kg-day | Rat | oral | chronic | HESS |
| NOEL | =94 mg/m3 | Rat | inhalation | subchronic | EU SCOEL |
| OEL | =66.3517 mg/m3 | Human | inhalation | - | EU SCOEL |
| LOAEC | =250 mg/kg-day | Rat | oral | - | ECHA |
| LOAEC | =250 mg/kg-day | Rat | oral | - | ECHA |
| NOAEC | =500 mg/kg-day | Rat | oral | - | ECHA |
| NOAEL | =500 mg/kg-day | Mouse | oral | - | ECHA |
| NOAEL | =500 mg/kg-day | Mouse | oral | - | ECHA |
| NOEL | =2050 mg/kg-day | Mouse | oral | short-term (developmental) | ECOTOX |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Eye Irrit. 2
Hazard Statements
- H319 Causes serious eye irritation
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Solvent in hair dye products. Max: 0.09.
BRIN Brazil/India Cosmetics
Brazil: Restricted
India: Restricted · max 0.09
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| BR | restricted | 9 | Solvent in hair dye products only; no aerosol systems |
| ASEAN | restricted | 9% | Hair dye products (as solvent) |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
EPA Dryad Skin Absorption (physics-based)
MW: 162.229
LogP: 0.56022
Kp epidermis: 0.00681 cm/h
% dose epidermis: 0.97%
% dose stratum corneum: 0.95%
% dose dermis: 0.93%
Source: EPA Dryad Skin Absorption 2024
Roberts Skin Permeation (Mendeley 2022)
MW: 162.23
Log Kow: 0.6
Log Kp: -2.166883050556182
Log Jmax: -4.346663265681909
Source: Roberts Cheruvu Mendeley 2022
Aggregated DA Values (5 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 50.0% | - | - | SCCP/0081 |
| default | 100.0% | - | - | SCCP/0081 |
| measured | 54.0% | - | - | SCCP/0081 |
| measured | 19.0% | - | - | SCCP/0081 |
| measured | 51.0% | - | - | SCCP/0081 |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
ICSC Safety Card
0788
Source: WHO/JECFA
Skin Eye Respiratory Irritation
DEGBE should be classified as irritating to the eyes. | Moderately irritating & injurious to eyes, not appreciably irritating to skin ... .
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chemical reaction regulator
Cleaning agent
Coalescing agent
Deodorizer
Diluent
Film former
Flow promoter
Fragrance
No specific technical function
Pigment
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Indirect Food Contact Additives
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Butoxydiglycol.
Regulatory Flags
epa_safer_alternative
ifra_fragrance
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Butoxydiglycol by CAS number or substance name.
Studies
25
Lowest NOAEL
2.6
Highest NOAEL
2000
Units vary across source rows: mg/kg, mg/kg bw/day, mg/kg bw/d
SCCS Opinion
ECHA
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 50.0% | - | - |
| 100.0% | - | - |
| 54.0% | - | - |
| 19.0% | - | - |
| 51.0% | - | - |
Known Synonyms
Diethylene glycol monobutyl ether
BRN 1739225
Butoxy diethylene glycol
Caswell No. 121B
Caswell No. 125H
Diethylene gylcol monobutyl ether
EINECS 203-961-6
EPA Pesticide Chemical Code 011502
Glycol ether DB
Jeffersol DB
UNII-9TB90IYC0E
Chemical Function
Solvent
Deodorizer
Viscosity modifier
Fragrance
Regulatory Lists
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe
detected; Other direct contact consumer goods
Arts and crafts/Office supplies - home office - pens and markers; detected; Europe
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe
Arts and crafts/Office supplies - fabric treatment and dye; detected
artificial_saliva; detected; emissions; Europe; Toys and children's products
Europe; Specialty occupational products
Europe; Specialty occupational products
Europe; Specialty occupational products
detected; Europe; Specialty occupational products
air; detected; emissions; Europe; Other indirect contact consumer goods
Cleaning products and household care - oven - oven cleaner; Europe
Cleaning products and household care - oven - oven cleaner; Europe
Cleaning products and household care - oven - oven cleaner; detected; Europe
air; Cons electronics mech appliances and machinery; detected; emissions; Europe
inert_ingredient; non_food_use; Pesticides
Cleaning products and household care - oven - oven cleaner; Europe
Cleaning products and household care - oven - oven cleaner; detected; Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1904721
Frequently Asked Questions
Is Butoxydiglycol allowed in the EU?
Butoxydiglycol EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Butoxydiglycol do in cosmetics?
Butoxydiglycol functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 112-34-5.
What is the NOAEL for Butoxydiglycol?
The NOAEL (No Observed Adverse Effect Level) for Butoxydiglycol is =2.6 mg/kg based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS Opinion.
Is Butoxydiglycol used outside cosmetics?
Butoxydiglycol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Butoxydiglycol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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