Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Butoxydiglycol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 250 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 200 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOAEL | 600 mg/kg bw/day | dermal | rat | dermal | REACH |
| LOAEL | 51 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 350 other | 1991 | rat | inhalation | REACH |
| NOAEL | 891 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 51 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 0.3 other | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Contains diethylene glycol moiety – verify that free DEG impurity is controlled below 0.1%; check specific max concentration per product type in Annex III
Regulatory Flags
Frequently Asked Questions
Is Butoxydiglycol safe in cosmetics?
Contains diethylene glycol moiety – verify that free DEG impurity is controlled below 0.1%; check specific max concentration per product type in Annex III The EU classifies Butoxydiglycol as "restricted". Safety rating: MODERATE. 8 toxicological study endpoint(s) are available in our database.
Is Butoxydiglycol allowed in the EU?
Butoxydiglycol EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Butoxydiglycol do in cosmetics?
Butoxydiglycol functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 112-34-5.
What is the Margin of Safety for Butoxydiglycol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Butoxydiglycol?
The NOAEL (No Observed Adverse Effect Level) for Butoxydiglycol is 250 mg/kg bw/day based on a oral study via oral route in rat. A total of 8 study endpoints are available. Source: REACH.
Compliance Tools
Check Butoxydiglycol compliance across multiple jurisdictions:
Related Ingredients
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