What is the NOAEL for 2-Phenylpropan-1-ol?
2-Phenylpropan-1-ol has 11 NOAEL studies in the database. The lowest reported value is 27ZYZ88DWU UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Phenylpropan-1-ol
Also known as: Benzeneethanol, .beta.-methyl-, Benzeneethanol, beta-methyl-, Phenethyl alcohol, beta-methyl-, 2-Phenylpropyl alcohol, 2-06-00-00477 (+14 more)
CAS 1123-85-9
2-Phenylpropan-1-ol (CAS 1123-85-9) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Hydratropic Alcohol (2-Phenyl-1-propanol) →
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
25 fields
Name
2-Phenylpropan-1-ol
CAS Number
1123-85-9
DTXSID
DTXSID8037756
Molecular Formula
C9H12O
InChI Key
RNDNSYIPLPAXAZ-UHFFFAOYSA-N
Monoisotopic Mass
136.088815
Synonyms
Benzeneethanol, .beta.-methyl-Benzeneethanol, beta-methyl-Phenethyl alcohol, beta-methyl-2-Phenylpropyl alcohol2-06-00-00477BRN 1906760EINECS 214-379-7FEMA No. 2732Hydratropic alcoholHydratropyl alcohol1-Hydroxy-2-phenylpropanealpha-Methyl phenylethyl alcohol
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 27ZYZ88DWU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 27ZYZ88DWU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 27ZYZ88DWU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 27ZYZ88DWU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 3876 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 3888 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =2300 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 40 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =10 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-phenylpropan-1-ol | 214-379-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
CHEMBL2323841
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Phenylpropan-1-ol?
2-Phenylpropan-1-ol appears on 4 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is 2-Phenylpropan-1-ol used in cosmetics?
Yes, 2-Phenylpropan-1-ol is also indexed as a cosmetic ingredient under the name Hydratropic Alcohol (2-Phenyl-1-propanol). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Phenylpropan-1-ol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 2-Phenylpropan-1-ol used outside industrial chemicals?
2-Phenylpropan-1-ol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.