Is Hydratropic Alcohol (2-Phenyl-1-propanol) safe in cosmetics?
Hydratropic Alcohol (2-Phenyl-1-propanol) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Hydratropic Alcohol (2-Phenyl-1-propanol)
Also known as: Benzeneethanol, .beta.-methyl-, Benzeneethanol, beta-methyl-, Phenethyl alcohol, beta-methyl-, 2-Phenylpropyl alcohol, 2-06-00-00477 (+13 more)
INCI: HYDRATROPIC ALCOHOL
Hydratropic Alcohol (2-Phenyl-1-propanol) (CAS 1123-85-9) is a cosmetic cosmetic ingredient functioning as Fragrance. NOAEL 10 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 1123-85-9 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-phenylpropan-1-ol
InChIKey
RNDNSYIPLPAXAZ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydratropic Alcohol (2-Phenyl-1-propanol).
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Hydratropic Alcohol (2-Phenyl-1-propanol) across SCCS product categories, with measured dermal absorption where available.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
3876 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [260] Kligman AM (1974): Report to RIFM, 25 September, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 3888 | - | - |
| HRIPT | - | 0 | 3876 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
1459
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-PHENYLPROPAN-1-OL | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/113 | FAS 54-JECFA 63/525
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
beta-METHYLPHENETHYL ALCOHOL | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/113 | FAS 54-JECFA 63/525
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Hydratropic Alcohol (2-Phenyl-1-propanol).
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
Benzeneethanol, .beta.-methyl-
Benzeneethanol, beta-methyl-
Phenethyl alcohol, beta-methyl-
2-Phenylpropyl alcohol
2-06-00-00477
BRN 1906760
EINECS 214-379-7
FEMA No. 2732
Hydratropyl alcohol
1-Hydroxy-2-phenylpropane
alpha-Methyl phenylethyl alcohol
beta-Methylbenzeneethanol
beta-Methylphenethyl alcohol
2-Methyl-2-phenylethanol
NSC 5232
beta-Phenylpropyl alcohol
1-Propanol, 2-phenyl-
UNII-27ZYZ88DWU
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL2323841
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
BETA-METHYLPHENETHYL ALCOHOL
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Hydratropic Alcohol (2-Phenyl-1-propanol) allowed in the EU?
Hydratropic Alcohol (2-Phenyl-1-propanol) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydratropic Alcohol (2-Phenyl-1-propanol) do in cosmetics?
Hydratropic Alcohol (2-Phenyl-1-propanol) functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 1123-85-9.
Is Hydratropic Alcohol (2-Phenyl-1-propanol) used outside cosmetics?
Hydratropic Alcohol (2-Phenyl-1-propanol) also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hydratropic Alcohol (2-Phenyl-1-propanol) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Good
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