NOAEL Data Cosmetic Ingredient

Tetramethylpyrazine

Also known as: 2,3,5,6-Tetramethylpyrazine, EINECS 214-391-2, FEMA No. 3237, 2,3,5,6-Tetramethyl pyrazine, Tetramethylpyrazin (+2 more)

CAS 1124-11-4

Tetramethylpyrazine (CAS 1124-11-4) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for Tetramethylpyrazine →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 13 fields

Name

Tetramethylpyrazine

CAS Number

1124-11-4

DTXSID

DTXSID6047070

Molecular Formula

C8H12N2

InChI Key

FINHMKGKINIASC-UHFFFAOYSA-N

Monoisotopic Mass

136.100048

Synonyms

2,3,5,6-TetramethylpyrazineEINECS 214-391-2FEMA No. 32372,3,5,6-Tetramethyl pyrazineTetramethylpyrazinUNII-V80F4IA5XGLiqustrazine

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records

FragranceFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records

List	Keyword	Source
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 6 of 6 studies

Value	Unit	Endpoint	Route	Species	Source
V80F4IA5XG	UNII	FDA UNII substance identifier	-	-	openFDA substances
V80F4IA5XG	UNII	FDA UNII substance identifier	-	-	openFDA substances
V80F4IA5XG	UNII	FDA UNII substance identifier	-	-	openFDA substances
V80F4IA5XG	UNII	FDA UNII substance identifier	-	-	openFDA substances
=1910	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
55	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB

Showing 6 of 6 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL LIGUSTRAZINE

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Tetramethylpyrazine?

Tetramethylpyrazine has 6 NOAEL studies in the database. The lowest reported value is V80F4IA5XG UNII. Source: openFDA substances.

What regulatory lists include Tetramethylpyrazine?

Tetramethylpyrazine appears on 3 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.

Is Tetramethylpyrazine used in cosmetics?

Yes, Tetramethylpyrazine is also indexed as a cosmetic ingredient under the name Tetramethylpyrazine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Tetramethylpyrazine come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Tetramethylpyrazine used outside industrial chemicals?

Tetramethylpyrazine also appears in cosmetics, pharmaceutical, cannabis databases.