Tetramethylpyrazine
INCI: TETRAMETHYLPYRAZINE (2,3,5,6-TETRAMETHYLPYRAZINE; ALSO KNOWN AS LIGUSTRAZINE)
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Tetramethylpyrazine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 55 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 55 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Primarily used at very low concentrations in fragrances. Has pharmacological activity (vasodilation, blood circulation) at higher doses — relevant only if used at atypical concentrations
Regulatory Flags
Frequently Asked Questions
Is Tetramethylpyrazine safe in cosmetics?
Primarily used at very low concentrations in fragrances. Has pharmacological activity (vasodilation, blood circulation) at higher doses — relevant only if used at atypical concentrations The EU classifies Tetramethylpyrazine as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.
Is Tetramethylpyrazine allowed in the EU?
Tetramethylpyrazine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetramethylpyrazine do in cosmetics?
Tetramethylpyrazine functions as: Fragrance — enhances and perfumes the product; also recognized for vasodilatory and anti-inflammatory properties in traditional medicine. It is classified as a cosmetic ingredient in our database. CAS number: 1124-11-4.
What is the Margin of Safety for Tetramethylpyrazine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Tetramethylpyrazine?
The NOAEL (No Observed Adverse Effect Level) for Tetramethylpyrazine is 55 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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