What is the NOAEL for (-)-Isolongifolene?
(-)-Isolongifolene has 4 NOAEL studies in the database. The lowest reported value is E0LN4V7EY4 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
(-)-Isolongifolene
Also known as: Isolongifolene (2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S,4aR)-), EINECS 214-494-2, Isolongifolene, iso-Longifolene, 2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-
CAS 1135-66-6
(-)-Isolongifolene (CAS 1135-66-6) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for HEXAHYDRO-TETRAMETHYL-METHANONAPHTHALENE →
Cross-Vertical Regulatory Divergence
(-)-Isolongifolene is classified GHS Danger (H304) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
(-)-Isolongifolene
CAS Number
1135-66-6
DTXSID
DTXSID1044518
Molecular Formula
C15H24
InChI Key
CQUAYTJDLQBXCQ-NHYWBVRUSA-N
Monoisotopic Mass
204.187801
Synonyms
Isolongifolene (2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S,4aR)-)EINECS 214-494-2Isolongifoleneiso-Longifolene2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| E0LN4V7EY4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| E0LN4V7EY4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| E0LN4V7EY4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| E0LN4V7EY4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene | 214-494-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3183415
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include (-)-Isolongifolene?
(-)-Isolongifolene appears on 4 regulatory/inventory lists including air; detected; emissions; Europe; Other direct contact consumer goods, IFRA Transparency, Europe, and 1 more. Source: EPA CPDat.
Is (-)-Isolongifolene used in cosmetics?
Yes, (-)-Isolongifolene is also indexed as a cosmetic ingredient under the name HEXAHYDRO-TETRAMETHYL-METHANONAPHTHALENE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for (-)-Isolongifolene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does (-)-Isolongifolene have different safety status in cosmetics vs industrial chemicals?
(-)-Isolongifolene is classified GHS Danger (H304) in the chemicals database but is allowed in EU cosmetics.
Is (-)-Isolongifolene used outside industrial chemicals?
(-)-Isolongifolene also appears in cosmetics, pharmaceutical, cannabis databases.