NOAEL Data REACH Registered Cosmetic Ingredient

2-Methyl-3-buten-2-ol

Also known as: 4-01-00-02132, BRN 1698263, 1,1-Dimethylallyl alchol, alpha,alpha-Dimethylallyl alcohol, 1,1-Dimethyl-2-propanol (+4 more)

CAS 115-18-4

2-Methyl-3-buten-2-ol (CAS 115-18-4) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for 2-Methyl-3-Buten-2-Ol →

Cross-Vertical Regulatory Divergence

2-Methyl-3-buten-2-ol is classified GHS Danger (H225, H302, H319, H336, H361) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 15 fields

Name

2-Methyl-3-buten-2-ol

CAS Number

115-18-4

DTXSID

DTXSID3047471

Molecular Formula

C5H10O

InChI Key

HNVRRHSXBLFLIG-UHFFFAOYSA-N

Monoisotopic Mass

86.073165

Synonyms

4-01-00-02132BRN 16982631,1-Dimethylallyl alcholalpha,alpha-Dimethylallyl alcohol1,1-Dimethyl-2-propanol1,1-Dimethyl-2-propenolEINECS 204-068-43-Methyl-buten-(1)-ol-(3)UNII-SH64HE46L9

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Highly flammable liquid and vapour Harmful if swallowed Causes eye irritation
Short-term Effects	The substance is irritating to the eyes.
Routes of Exposure	The substance can be absorbed into the body by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 5 records

FragranceFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records

List	Keyword	Source
active_ingredient; Europe; Pesticides	European Commission	CPCat
IFRA Transparency	IFRA	IFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product	P&G	Proctor & Gamble
Europe	European Commission	Fl@vis

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 11 of 11 studies

Value	Unit	Endpoint	Route	Species	Source
SH64HE46L9	UNII	FDA UNII substance identifier	-	-	openFDA substances
SH64HE46L9	UNII	FDA UNII substance identifier	-	-	openFDA substances
SH64HE46L9	UNII	FDA UNII substance identifier	-	-	openFDA substances
SH64HE46L9	UNII	FDA UNII substance identifier	-	-	openFDA substances
>21.2	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=85220	mg/m3	LEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=112250	mg/m3	LEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=200	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=50	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=150	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
1250	mg/kg bw/day	NOAEL	oral	mouse	COSMOS_DB

Showing 11 of 11 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	2-methylbut-3-en-2-ol	204-068-4	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL4245903

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 2-Methyl-3-buten-2-ol?

2-Methyl-3-buten-2-ol has 11 NOAEL studies in the database. The lowest reported value is SH64HE46L9 UNII. Source: openFDA substances.

What regulatory lists include 2-Methyl-3-buten-2-ol?

2-Methyl-3-buten-2-ol appears on 5 regulatory/inventory lists including active_ingredient; Europe; Pesticides, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 2 more. Source: EPA CPDat.

Is 2-Methyl-3-buten-2-ol used in cosmetics?

Yes, 2-Methyl-3-buten-2-ol is also indexed as a cosmetic ingredient under the name 2-Methyl-3-Buten-2-Ol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Methyl-3-buten-2-ol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Methyl-3-buten-2-ol have different safety status in cosmetics vs industrial chemicals?

2-Methyl-3-buten-2-ol is classified GHS Danger (H225, H302, H319, H336, H361) in the chemicals database but is allowed in EU cosmetics.

Is 2-Methyl-3-buten-2-ol used outside industrial chemicals?

2-Methyl-3-buten-2-ol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.